PTAFR
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Official Full Name
Platelet-Activating Factor Receptor
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Overview
PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling. Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain. In leukocyte cell populations the receptor is found on platelets, myocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor. Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells. -
Synonyms
PTAFR; platelet-activating factor receptor; PAFR; PAF-R; OTTHUMP00000004040; OTTHUMP00000004041; PAF Receptor;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Cavia porcellus (Guinea pig)
- Goat
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- E.coli expression system
- HEK293
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- Flag
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PTAFR Related Articles
- PTAFR Related Research Area
PTAFR involved in several pathways and played different roles in them. We selected most pathways PTAFR participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTAFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Calcium signaling pathway | EDNRA;DRD1A;ATP2A2B;TACR2;EDNRB2;CALM;GNAL;P2RX8;PRKCA |
Neuroactive ligand-receptor interaction | THRA;LPAR6A;ADRB2B;GNRHR1;AVPR1B;TAAR4;GPR156;VIPR2;GRIA3B |
Staphylococcus aureus infection | SELP;ITGAM;C5;HLA-DOA;FGG;GM5077;MBL2;FPR1;HLA-DMB |
PTAFR has several biochemical functions, for example, G-protein coupled purinergic nucleotide receptor activity, G-protein coupled receptor activity, lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTAFR itself. We selected most functions PTAFR had, and list some proteins which have the same functions with PTAFR. You can find most of the proteins on our site.
Function | Related Protein |
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G-protein coupled purinergic nucleotide receptor activity | P2RY11;PTAFR;GPR34B;P2RY4;GPR171;P2RY1;P2RY13;P2RY2;P2RY14 |
G-protein coupled receptor activity | OR2A42;GPR173;GPR52;TAS2R108;CD97;FZD8B;OLFCG1;GHRHRL;GPR65 |
lipopolysaccharide binding | KIAA0644;PTAFR;BPI;PSMB4;HSPD1;SPON2;TLR4;BPIFC;HMGB1 |
lipopolysaccharide receptor activity | PTAFR;TLR2;TLR4;LY96;SCARB1 |
phospholipid binding | BAIAP2L2;OSBPL1A;SYTL4;TICAM2;APOEB;GLTPD1;PACSIN1A;ANXA1;PRKCI |
platelet activating factor receptor activity | PTAFR;PDGFRB;PDGFRL |
PTAFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTAFR here. Most of them are supplied by our site. Hope this information will be useful for your research of PTAFR.
CALM1; GORAB; SPATA24; GTPBP3
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