ptafr
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  • Official Full Name
  • Platelet-Activating Factor Receptor
  • Background
  • PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling. Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain. In leukocyte cell populations the receptor is found on platelets, myocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor. Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells.
  • Synonyms
  • PTAFR; platelet-activating factor receptor; PAFR; PAF-R; OTTHUMP00000004040; OTTHUMP00000004041; PAF Receptor
Cat.#:PTAFR-13618MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTAFR Protein
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Cat.#:PTAFR-4795RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTAFR Protein
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Cat.#:PTAFR-2731HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PTAFR 293 Cell Lysate
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Cat.#:Kit-1484Tag:N/A
Source (Host):Species:
Product namePTAFR CHO-K1 β-Arrestin GPCR Assay Kit
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Involved Pathway

PTAFR involved in several pathways and played different roles in them. We selected most pathways PTAFR participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTAFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
DRD5; GNA11A; CALM1A; VDAC2; CACNA1BA; ORAI2; PTGER1C; ATP2B1A; P2RX6; ATP2B1
Neuroactive ligand-receptor interaction
LEP; F2; GABRA5; CHRNA2; AGTR1A; THRAA; DRD2B; PRL; NPFFR1L2; PRL2
Staphylococcus aureus infection
C1QC; FCGR3A; HLA-DRB4; HLA-DOA; FCGR2A; FCGR2C; H2-AA; C3AR1; C1QB; FCGR3

Protein Function

PTAFR has several biochemical functions, for example, G-protein coupled purinergic nucleotide receptor activity, G-protein coupled receptor activity, lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTAFR itself. We selected most functions PTAFR had, and list some proteins which have the same functions with PTAFR. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled purinergic nucleotide receptor activity
Related Protein PTAFR; GPR34B; P2RY4; P2RY11; P2RY13; P2RY10; GPR171; P2RY1; P2RY6; P2RY14
Function G-protein coupled receptor activity
Related Protein FPR-RS4; OR51B4; FZD9B; CCR7; TAS2R107; OPRD1A; RRH; OLFR488; ELTD1; OPRD1B
Function lipopolysaccharide binding
Related Protein PTAFR; CATHL3; RNASE7; SCARB1; P2RX7; CD6; SELP; SPON2; DROSHA; PSMB4
Function lipopolysaccharide receptor activity
Related Protein PTAFR; TLR2; TLR4; SCARB1; LY96
Function phospholipid binding
Related Protein PACSIN1A; PRKCI; APOEB; SPTBN1; NUP35; NR5A1; PTAFR; RASAL1; NBEA; MTAP1B
Function platelet activating factor receptor activity
Related Protein PDGFRB; PDGFRL; PTAFR

Interacting Protein

PTAFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTAFR here. Most of them are supplied by our site. Hope this information will be useful for your research of PTAFR.
CALM1; GORAB; SPATA24; GTPBP3

PTAFR Related Articles

Leoni, G; Gripentrog, J; et al. Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response. JOURNAL OF LEUKOCYTE BIOLOGY 97:87-101(2015).
Yu, Y; Zhang, MX; et al. Transactivation of epidermal growth factor receptor through platelet- activating factor/receptor in ovarian cancer cells. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 33:-(2014).