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PTGR1

  • Official Full Name

    prostaglandin reductase 1

  • Overview

    This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants.
  • Synonyms

    PTGR1; prostaglandin reductase 1; leukotriene B4 12 hydroxydehydrogenase , LTB4DH; ZADH3; zinc binding alcohol dehydrogenase domain containing 3; PRG-1; 15-oxoprostaglandin 13-reductase; leukotriene B4 12-hydroxydehydrogenase; NADP-dependent leukotriene B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTGR1-2520H Recombinant Human Prostaglandin Reductase 1, His-tagged E.coli His 1-329aa
Human PTGR1-2048H Recombinant Human PTGR1, GST-tagged E.coli GST 1-329aa
Human PTGR1-2708HCL Recombinant Human PTGR1 293 Cell Lysate HEK293 N/A
Human PTGR1-4593H Recombinant Human PTGR1 Protein, GST-tagged Wheat Germ GST
Human PTGR1-1794H Recombinant Human PTGR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTGR1-354HFL Active Recombinant Full Length Human PTGR1 Protein, C-Flag-tagged Mammalian cells Flag
Human PTGR1-1794H-B Recombinant Human PTGR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ptgr1-5223M Recombinant Mouse Ptgr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PTGR1-4814R Recombinant Rat PTGR1 Protein Mammalian Cell His
Rat PTGR1-4473R Recombinant Rat PTGR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTGR1-4473R-B Recombinant Rat PTGR1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PTGR1-1936Z Recombinant Zebrafish PTGR1 Mammalian Cell His
Chicken PTGR1-3084C Recombinant Chicken PTGR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTGR1 Related Articles

PTGR1 involved in several pathways and played different roles in them. We selected most pathways PTGR1 participated on our site, such as Arachidonic acid metabolism, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismPTGDSB;CYP2AD6;PLA2G4F;CYP4F2;HPGDS;PTGS2;AWAT2;CYP4A12A;PTGIS
MetabolismAPOEB;CYP2AD6;GDF1;Gpc2;CYP3C4;ACOT9.2;ACOT11;Agmo;ACOT8
Metabolism of lipids and lipoproteinsMED6;ACOT9.2;CYP24A1;CERS5;ESRRA;MED15;CDS1;MED23;MED31
Synthesis of Leukotrienes (LT) and Eoxins (EX)ALOX5B.3;ALOX5AP;PTGR1;ALOX5B.2;DPEP1;DPEP2
Synthesis of Lipoxins (LX)PTGR1;ALOX5B.3;ALOX5B.2
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)PTGR1;PTGDSA;FAM213B
sphingosine and sphingosine-1-phosphate metabolismACER1;PTGR1

PTGR1 has several biochemical functions, for example, 13-prostaglandin reductase activity, 15-oxoprostaglandin 13-oxidase activity, 2-alkenal reductase [NAD(P)] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGR1 itself. We selected most functions PTGR1 had, and list some proteins which have the same functions with PTGR1. You can find most of the proteins on our site.

Function Related Protein
13-prostaglandin reductase activityPTGR1;PTGR2
15-oxoprostaglandin 13-oxidase activityPTGR1;PTGR2
2-alkenal reductase [NAD(P)] activity
zinc ion bindingPIAS4;MMP17;RNF207;MTA3;UBR4;NR1D1;PCGF1;ABLIM1B;GCM1

PTGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGR1.

ychF

Zhao, RJ; Pan, ZY; et al. Stimulation of non-neuronal muscarinic receptors enhances chemerin/ChemR23 system in dysfunctional endothelial cells. LIFE SCIENCES 92:10-16(2013).
Naidansuren, P; Park, CW; et al. Molecular characterization of bovine placental and ovarian 20 alpha-hydroxysteroid dehydrogenase. REPRODUCTION 142:723-731(2011).
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