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PTRF

  • Official Full Name

    polymerase I and transcript release factor

  • Overview

    This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3 end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]
  • Synonyms

    PTRF; polymerase I and transcript release factor; CGL4; CAVIN; CAVIN1; FKSG13; cavin-1; TTF-I interacting peptide 12; RNA polymerase I and transcript release factor;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • HEK293
  • Mammalian Cell
  • Mouse
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTRF-1442HCL Recombinant Human PTRF cell lysate N/A
Human PTRF-3163H Recombinant Human PTRF Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DMABT-H14716 Mouse Anti-PTRF Monoclonal Antibody Mouse N/A
Mouse PTRF-13711M Recombinant Mouse PTRF Protein Mammalian Cell His
Mouse PTRF-7294M Recombinant Mouse PTRF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PTRF-7294M-B Recombinant Mouse PTRF Protein Pre-coupled Magnetic Beads HEK293
Chicken PTRF-1114C Recombinant Chicken PTRF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PTRF involved in several pathways and played different roles in them. We selected most pathways PTRF participated on our site, such as Gene Expression, RNA Polymerase I Transcription, RNA Polymerase I Transcription Termination, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTRF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionZNF257;ZNF599;CDK9;SAP30;SETB;WDR77;NFIX;KHSRP;ZNF549
RNA Polymerase I TranscriptionMBD3;TAF1B;PTRF;EFCAB11;TAF1C;MTA2;CHD4;GATAD2AB;PTRFB
RNA Polymerase I Transcription TerminationPTRFB;UBTF;PTRF
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionPOLR3GLA;POLRMT;ZFP143;CHD4;SNAPC1;GATAD2B;TFB2M;BRF2;SNAPC2

PTRF has several biochemical functions, for example, poly(A) RNA binding, protein binding, rRNA primary transcript binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTRF itself. We selected most functions PTRF had, and list some proteins which have the same functions with PTRF. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingRPS15A;MRPL28;WBP11;PCBP1;KHDRBS3;PTBP2;ZCCHC17;NOL11;NME1
protein bindingCOMMD10;MATN4;PLK2;TACC1;GGA2;PCK2;XIRP2;MAP3K9;EDARADD
rRNA primary transcript bindingNCL;RPF1;IMP4;PTRF

PTRF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTRF here. Most of them are supplied by our site. Hope this information will be useful for your research of PTRF.

Incenp; midostaurin; ssrna_ug; Flot1; ATP6AP2; MYC; PTPN1; RAB5A; Rab5c; Bmpr1a; RAB5C; RAB7A; RAB2A; CKAP5; DBN1

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