pxn
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  • Official Full Name
  • paxillin
  • Background
  • This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the;extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been;described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well;as physiological properties (PMID:9054445).
  • Synonyms
  • PXN; paxillin; FLJ16691
Cat.#:PXN-029HTag:Trx, His and S-tags
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PXN Protein, Trx, His and S-tags-tagged
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Cat.#:PXN-030HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PXN Protein, His-tagged
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Cat.#:PXN-2083HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PXN, His-tagged
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Cat.#:PXN-2413HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Paxillin, GST-tagged
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Cat.#:PXN-29060THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PXN
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Cat.#:Pxn-1874MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pxn protein, His & T7-tagged
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Cat.#:Pxn-1875RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pxn protein, His & T7-tagged
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Cat.#:PXN-4856RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PXN Protein
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Cat.#:PXN-6542CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PXN
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Cat.#:PXN-2651HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PXN 293 Cell Lysate
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Involved Pathway

PXN involved in several pathways and played different roles in them. We selected most pathways PXN participated on our site, such as Chemokine signaling pathway, VEGF signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PXN were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
PTK2B; RAC2; PPBP; CCR9; PRKACA; MAPK1; CCL19; PLCB3; ADRBK1; VAV1
VEGF signaling pathway
NFATC2; MAPK11; PTGS2; PTK2; CDC42L; VEGFA; PLCG2; PPP3CCB; PRKCBB; MAP2K2A
Focal adhesion
MYL2; MYL12A; PAK6; PTENB; PIK3CG; PPP1CA; RHOAD; CAV1; FYNA; RHOAC
Leukocyte transendothelial migration
NCF2; CXCL12; PIK3R3; CDH5; MYL5; PRKCB; ITGB2L; MAPK11; CLDN2; MYL7
Regulation of actin cytoskeleton
TMSB4Y; SCINLA; ENAH; ITGB6; MLCK2; MAPK1; PAK6; WASLA; PIKFYVE; ITGA3B
Bacterial invasion of epithelial cells
CDC42; SHC4; DNM1; PIK3R1; SEPT12; ARPC3; GAB1; PIK3CG; PIK3R2; ITGA5
Viral carcinogenesis
EIF2AK2; HDAC8; TBPL1; CREB3L2; PXN; GTF2H1; PRKACA; HIST1H4D; GTF2A1L; DDX3X
Proteoglycans in cancer
FZD8; CAMK2G; CTTN; RPS6KB2; MAP2K2; IGF1; PLCE1; TLR2; WNT8B; TLR4

Protein Function

PXN has several biochemical functions, for example, BH4 domain binding, beta-catenin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PXN itself. We selected most functions PXN had, and list some proteins which have the same functions with PXN. You can find most of the proteins on our site.
Function
Related Protein
Function BH4 domain binding
Related Protein PXN
Function beta-catenin binding
Related Protein C; PROP1; CD2AP; NUMB; PTPRJ; CDH1; ESR1; TCF7L2; NF2; TBL1X
Function integrin binding
Related Protein ADAM23; THBS1; SYK; ILK; ADAMTS8; CTGFA; ICAM1; LAMA5; ITGB1BP2; ACTN2
Function protein binding
Related Protein SH3GL1; RPL13; KLHL41; MC5R; SPATA8; SERPINE2; MLKL; OGFR; HIST2H4; ZNF32
Function protein kinase binding
Related Protein NEK9; IL31RA; JAK2; KCNA5; IFNAR2; FAM83E; RFFL; CCNL2; SMAD1; NME2
Function vinculin binding
Related Protein PXN; DAG1; C22orf28; SORBS3; ACTN1; TLN1; DMD; SYNM; NRAP; CTNNA1
Function zinc ion binding
Related Protein ZFML; RNF215; AJUBA; MAN2C1; ZDHHC1; CA5; ADAMTS10; NR2F6A; SRSF7A; RNF113B

Interacting Protein

PXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PXN here. Most of them are supplied by our site. Hope this information will be useful for your research of PXN.
PTK2; PTPN11; Sorbs1