|Official Full Name||paxillin|
|Background||This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the;extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been;described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well;as physiological properties (PMID:9054445).|
|Synonyms||PXN; paxillin; FLJ16691|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PXN involved in several pathways and played different roles in them. We selected most pathways PXN participated on our site, such as Chemokine signaling pathway, VEGF signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Chemokine signaling pathway||GNG3; GNG4; MAP2K1; CCL7; XCR1; CCR1; JAK3; GNG2; GM1987; SHC3|
|VEGF signaling pathway||PIK3R3B; VEGFAB; PRKCBB; MAPK14B; PPP3CCB; MAPK14A; MAPKAPK2A; PPP3R2; PTGS2B; PIK3CG|
|Focal adhesion||MYLK2; SPP1; COL27A1B; VTN; MYL2B; CAV1; PTENA; PIK3CG; GSK3B; COL4A1|
|Leukocyte transendothelial migration||CLDN23; PLCG2; PIK3R5; ACTN3; MMP2; ACTN2; MYL10; CLDN1; CLDN10; CLDN3|
|Regulation of actin cytoskeleton||ITGB2L; CFL2; PDGFAB; VCL; FGF20B; ITGAV; ITGA3; VAV3; BRK1; ACTN3A|
|Bacterial invasion of epithelial cells||SRC; CBL; MAD2L2; CAV2; DNM2; WAS; CRK; ARPC5L; SEPT1; PIK3CD|
|Viral carcinogenesis||GTF2H4; PMAIP1; HRAS; POLB; CDC20; ACTN3; IRF3; CCNE2; SNW1; HIST1H2BL|
|Proteoglycans in cancer||Fzd4; AKT1; TWIST2; TGFB2; ITGB3; PRKACA; ITGB1; FGF2; KRAS; HIF1A|
PXN has several biochemical functions, for example, BH4 domain binding, beta-catenin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PXN itself. We selected most functions PXN had, and list some proteins which have the same functions with PXN. You can find most of the proteins on our site.
|BH4 domain binding||PXN|
|beta-catenin binding||CDH5; PTPRK; GLI3; SMAD3; TCF7L1A; CARM1; SMAD7; HDAC6; RORA; DACT3|
|integrin binding||ANXA7; PXN; EMP2; CYR61; ADAM25; DMP1; THBS4; ITGA5; CD151; TIMP2|
|protein binding||EPB41; EXO1; HIP1R; PCGF3; USP2; VPS18; ZNF652; MYOM1; SLC9A3R2; TEN1|
|protein kinase binding||NEFH; GDF3; USP37; CSPG4; EEF2; ERRFI1; PIFO; TNNI3; DVL1; PPP1R15A|
|vinculin binding||PXN; NRAP; ACTN1; C22orf28; DAG1; SYNM; CTNNA1; DMD; TLN1; SORBS3|
|zinc ion binding||FHL2A; MMP26; SIAH2L; ADAM28; RNF4; LONRF2; TRIM35-23; AEBP1; RECQL4; SEC23B|
PXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PXN here. Most of them are supplied by our site. Hope this information will be useful for your research of PXN.
PTK2; PTPN11; Sorbs1