PXN

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PXN

Official Full Name paxillin
Background This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the;extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been;described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well;as physiological properties (PMID:9054445).
Synonyms PXN; paxillin; FLJ16691
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    • Trx
    • S
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PXN-1138H Recombinant Human PXN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Pxn-5268M Recombinant Mouse Pxn Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PXN-029H Recombinant Human PXN Protein, Trx, His and S-tags-tagged E.coli Trx/His/S
    Human PXN-030H Recombinant Human PXN Protein, His-tagged E.coli His
    Human PXN-2083H Recombinant Human PXN, His-tagged E.coli His
    Human PXN-2413H Recombinant Human Paxillin, GST-tagged E.coli GST
    Human PXN-2651HCL Recombinant Human PXN 293 Cell Lysate HEK293 N/A
    Human PXN-29060TH Recombinant Human PXN E.coli N/A
    Mouse Pxn-1874M Recombinant Mouse Pxn protein, His & T7-tagged E.coli His/T7
    Rat Pxn-1875R Recombinant Rat Pxn protein, His & T7-tagged E.coli His/T7
    Rat PXN-4856R Recombinant Rat PXN Protein Mammalian Cell His
    Chicken PXN-6542C Recombinant Chicken PXN Mammalian Cell His

    PXN involved in several pathways and played different roles in them. We selected most pathways PXN participated on our site, such as Chemokine signaling pathway, VEGF signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine signaling pathway GNG3; GNG4; MAP2K1; CCL7; XCR1; CCR1; JAK3; GNG2; GM1987; SHC3
    VEGF signaling pathway PIK3R3B; VEGFAB; PRKCBB; MAPK14B; PPP3CCB; MAPK14A; MAPKAPK2A; PPP3R2; PTGS2B; PIK3CG
    Focal adhesion MYLK2; SPP1; COL27A1B; VTN; MYL2B; CAV1; PTENA; PIK3CG; GSK3B; COL4A1
    Leukocyte transendothelial migration CLDN23; PLCG2; PIK3R5; ACTN3; MMP2; ACTN2; MYL10; CLDN1; CLDN10; CLDN3
    Regulation of actin cytoskeleton ITGB2L; CFL2; PDGFAB; VCL; FGF20B; ITGAV; ITGA3; VAV3; BRK1; ACTN3A
    Bacterial invasion of epithelial cells SRC; CBL; MAD2L2; CAV2; DNM2; WAS; CRK; ARPC5L; SEPT1; PIK3CD
    Viral carcinogenesis GTF2H4; PMAIP1; HRAS; POLB; CDC20; ACTN3; IRF3; CCNE2; SNW1; HIST1H2BL
    Proteoglycans in cancer Fzd4; AKT1; TWIST2; TGFB2; ITGB3; PRKACA; ITGB1; FGF2; KRAS; HIF1A

    PXN has several biochemical functions, for example, BH4 domain binding, beta-catenin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PXN itself. We selected most functions PXN had, and list some proteins which have the same functions with PXN. You can find most of the proteins on our site.

    Function Related Protein
    BH4 domain binding PXN
    beta-catenin binding CDH5; PTPRK; GLI3; SMAD3; TCF7L1A; CARM1; SMAD7; HDAC6; RORA; DACT3
    integrin binding ANXA7; PXN; EMP2; CYR61; ADAM25; DMP1; THBS4; ITGA5; CD151; TIMP2
    protein binding EPB41; EXO1; HIP1R; PCGF3; USP2; VPS18; ZNF652; MYOM1; SLC9A3R2; TEN1
    protein kinase binding NEFH; GDF3; USP37; CSPG4; EEF2; ERRFI1; PIFO; TNNI3; DVL1; PPP1R15A
    vinculin binding PXN; NRAP; ACTN1; C22orf28; DAG1; SYNM; CTNNA1; DMD; TLN1; SORBS3
    zinc ion binding FHL2A; MMP26; SIAH2L; ADAM28; RNF4; LONRF2; TRIM35-23; AEBP1; RECQL4; SEC23B

    PXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PXN here. Most of them are supplied by our site. Hope this information will be useful for your research of PXN.

    PTK2; PTPN11; Sorbs1

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