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Prkar2b

  • Official Full Name

    protein kinase, cAMP-dependent, regulatory, type II, beta

  • Overview

    cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
  • Synonyms

    PRKAR2B; protein kinase, cAMP-dependent, regulatory, type II, beta; PRKAR2; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; WUGSC:H_RG363E19.2; cAMP-dependent protein kinase type II-beta regulatory chain; RII-BETA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKAR2B-1952H Recombinant Human PRKAR2B, His-tagged E.coli His 1-418aa
Human PRKAR2B-1501H Recombinant Human PRKAR2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRKAR2B-2860HCL Recombinant Human PRKAR2B 293 Cell Lysate HEK293 N/A
Human PRKAR2B-398H Recombinant Human PRKAR2B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PRKAR2B-1953H Recombinant Human PRKAR2B protein, His-tagged E.coli His 1-122 aa
Human PRKAR2B-301518H Recombinant Human PRKAR2B protein, GST-tagged E.coli GST Met1-Pro122
Mouse PRKAR2B-13360M Recombinant Mouse PRKAR2B Protein Mammalian Cell His
Mouse PRKAR2B-7091M-B Recombinant Mouse PRKAR2B Protein Pre-coupled Magnetic Beads HEK293
Mouse Prkar2b-5117M Recombinant Mouse Prkar2b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PRKAR2B-7091M Recombinant Mouse PRKAR2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRKAR2B-4676R Recombinant Rat PRKAR2B Protein Mammalian Cell His
Rat Prkar2b-609R Recombinant Rat Prkar2b E.coli N/A
Rat PRKAR2B-4335R-B Recombinant Rat PRKAR2B Protein Pre-coupled Magnetic Beads HEK293
Rat PRKAR2B-4335R Recombinant Rat PRKAR2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Prkar2b involved in several pathways and played different roles in them. We selected most pathways Prkar2b participated on our site, such as Apoptosis, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prkar2b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisAIFM1;BIRC2;IL1B;CASP7;PIK3CG;OCLN;CASP9;H1F0;STK26
Insulin signaling pathwaySHC3;G6PCA.1;PCK1;CBLC;PIK3R3B;CBL;FLOT2;PRKAR1A;PRKAB2

Prkar2b has several biochemical functions, for example, cAMP binding, cAMP-dependent protein kinase inhibitor activity, cAMP-dependent protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Prkar2b itself. We selected most functions Prkar2b had, and list some proteins which have the same functions with Prkar2b. You can find most of the proteins on our site.

Function Related Protein
cAMP bindingPOPDC2;RAPGEF4;PDE4B;PDE11A;PDE3A;CNGA4;PRKAR2B;PDE10A;CNGA2
cAMP-dependent protein kinase inhibitor activityPKIA;PKIB;PRKAR2B;PRKAR1A;PRKAR2A;PRKAG2;PRKAR1B;PKIG
cAMP-dependent protein kinase regulator activityCXCL10;PRKAR1AA;PRKAR1AB;PRKAR2A;PRKAR2B;PRKAG2;PRKAR1A;PRKAG1;PRKAR2AA
protein domain specific bindingWNT5A;HIST1H4I;HOXB1;SCN5A;ARL1;ZBTB16;ACTN2;HOMER2;ARFIP1
protein kinase A catalytic subunit bindingEZR;PKIA;GSK3B;GSK3A;PRKAR2B;PJA2;PRKAR1B;KCNQ1;RYR2
ubiquitin protein ligase bindingCDKN1A;NFKBIA;MID1;PRKAR2B;WASH1;TRAF4;TSG101;TNFRSF1B;CDC34B

Prkar2b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prkar2b here. Most of them are supplied by our site. Hope this information will be useful for your research of Prkar2b.

PRKACA; 3',5'-cyclic amp; PRKACB; ARFGEF2; 7-ch-c_amp; sp-8-br-7-ch-camps; 7-ch-cgmp; kemptide; p03259-2; 2_aha_camp; 8-aha-camp; 8-aha-omethyladenosine; PCM1

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