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REST

Official Full Name

RE1-silencing transcription factor
Overview

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
Synonyms

REST; RE1-silencing transcription factor; XBR; NRSF; repressor binding to the X2 box; neural-restrictive silencer factor; neuron restrictive silencer factor; RE1-silencing transcription factor variant E1a/E2/E4; RE1-silencing transcription factor variant E1a/E2/E3/E5; RE1-silencing transcription factor variant E1b/E2/E3/E5; RE1-silencing transcription factor variant E1c/E2/E3/E5; RE1-silencing transcription factor variant E1a/E2/E3/E4c; RE1-silencing transcription factor variant E1c/E2g/E3/E4; RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i; RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i; RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4; RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	REST-2417HCL	Recombinant Human REST 293 Cell Lysate	HEK293	N/A		Inquiry
Human	REST-6173H	Recombinant Human REST Protein (Glu748-Glu1097), N-His tagged	E.coli	N-His	Glu748-Glu1097	Inquiry
Mouse	REST-14084M	Recombinant Mouse REST Protein	Mammalian Cell	His		Inquiry
Mouse	REST-7530M	Recombinant Mouse REST Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	REST-7530M-B	Recombinant Mouse REST Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	REST-5000R	Recombinant Rat REST Protein	Mammalian Cell	His		Inquiry
Rat	REST-4659R-B	Recombinant Rat REST Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	REST-4659R	Recombinant Rat REST Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
REST Related Articles

REST involved in several pathways and played different roles in them. We selected most pathways REST participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with REST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells	REST;ACVR2A;NODAL;PIK3CB;PCGF3;WNT8A;PCGF6;INHBB;WNT7B
Huntingtons disease	DNAL4;NDUFA10;COX7A1;COX7A2;UCP1;NDUFB4;SDHA;NDUFB10;IFT57

REST has several biochemical functions, for example, chromatin binding, core promoter binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REST itself. We selected most functions REST had, and list some proteins which have the same functions with REST. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	NFKB2;ATXN7;HMGB2B;MSH6;LDB2A;CTBP2;SUPT5H;EGFR;NKAP
core promoter binding	MED1;HMGA2;NONO;HDAC6;SFPQ;HDAC5;HNRNPU;PSPC1;MTA1
core promoter sequence-specific DNA binding	GATA3;ESR2;RORA;SOHLH2;SP1;PPARG;REST;PRMT5;ZFP932
metal ion binding	ADCY6;KALRN;LIMCH1A;FDPS;SDHDA;ACACB;ZBTB24;ZFP865;VSNL1A
outward rectifier potassium channel activity	KCNB1;KCNK18;KCNK1A;KCNQ1;REST;KCNK2B;KCNK5B;KCNA5;KCNK2
protein binding	KRTAP19-7;CLDN7;RRAS2;IWS1;SPSB4;SFTPC;RGS2;IFIT2;SCAMP1
transcription factor activity, sequence-specific DNA binding	HIF1AL;ZFP131;CBFA2T2;ZNF711;TA;CREB3L3A;TP73;TBX2B;PRDM15
transcription factor binding	BCL3;EP300;HDAC5;KCNA3;POU5F1;MAPK1;UBN1;IFI203;NKX2-5
transcription regulatory region DNA binding	ARID5B;ZNF649;NKX3;TP63;SERPINB1A;GATA6;SOX17;SALL1;GATA5
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	MAFBA;MAFA;EP300;CSRNP1;NKX2;GATA4;ZGLP1;MAFK;FOXF1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	PROX1A;NFE2L3;GATA1;DLX4;HINFP;ATF3;HHEX;TCF21;SP3

REST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REST here. Most of them are supplied by our site. Hope this information will be useful for your research of REST.

SMARCA4; SMARCC2; SMARCE1

Elbeshehy, EKF; Metwali, EMR; et al. Antiviral activity of Thuja orientalis extracts against watermelon mosaic virus (WMV) on Citrullus lanatus. SAUDI JOURNAL OF BIOLOGICAL SCIENCES 22:211-219(2015).

Diaz-Torne, C; Perez-Herrero, N; et al. New medications in development for the treatment of hyperuricemia of gout. CURRENT OPINION IN RHEUMATOLOGY 27:164-169(2015).