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  • Official Full Name
  • RE1-silencing transcription factor
  • Background
  • This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
  • Synonyms
  • REST; RE1-silencing transcription factor; XBR; NRSF; repressor binding to the X2 box; neural-restrictive silencer factor; neuron restrictive silencer factor; RE1-silencing transcription factor variant E1a/E2/E4; RE1-silencing transcription factor variant E1a/E2/E3/E5; RE1-silencing transcription factor variant E1b/E2/E3/E5; RE1-silencing transcription factor variant E1c/E2/E3/E5; RE1-silencing transcription factor variant E1a/E2/E3/E4c; RE1-silencing transcription factor variant E1c/E2g/E3/E4; RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i; RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i; RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4; RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j;
Cat.#:REST-14084MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse REST Protein
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Cat.#:REST-5000RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat REST Protein
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Cat.#:REST-2417HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human REST 293 Cell Lysate
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Involved Pathway

REST involved in several pathways and played different roles in them. We selected most pathways REST participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with REST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells
RAF1; LIF; FZD6; FZD1; PIK3R2; BMI1; ID3; IGF1; Fzd4; AKT1
Huntingtons disease
Atp5g2; SDHA; NDUFA9; POLR2K; SLC25A6; mt-Atp8; NDUFS6; DNAI1; DNAL1; RCOR1

Protein Function

REST has several biochemical functions, for example, chromatin binding, core promoter binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REST itself. We selected most functions REST had, and list some proteins which have the same functions with REST. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein FOSL2; MCMBP; GABPA; PKN1; SMC1AL; SOX9; ATF2; PPARG; TAL1; RBPJL
Function core promoter binding
Related Protein EP300; AGO1; E2F1; MYOD1; HMGA2; ARNTL; GATA1; HDAC1; ELK1; NKX2-1
Function core promoter sequence-specific DNA binding
Related Protein THRAP3; SOX1; CREM; TRP53; TOP1; CHD2; ESR2; SOX9; MTA1; SP1
Function metal ion binding
Related Protein CYBASC3; FDPS; COL18A1; UQCRC2A; ZFP36L1; ZSCAN20; PHC2A; TRIM43B; ZSCAN2; INO80B
Function outward rectifier potassium channel activity
Related Protein KCNK1A; KCNK18; KCNA5; KCNQ1; REST; KCNK5B; KCNB1; KCNK2; KCNK2B
Function protein binding
Related Protein CNOT1; CD74; IQSEC3; PRTFDC1; FGF10; F10; VCP; SSBP3; PLA2G16; HUS1
Function transcription factor activity, sequence-specific DNA binding
Related Protein DMRT2B; ZNF561; THRAA; TRIM25; ZNF45; REL; TSC22D2; HMGA1B; FOXO1A; EF1
Function transcription factor binding
Related Protein TRAPPC2; TAF7L; Ar; PBX1; KDM1A; GTF2F1; E2F5; HES6; AGTR2; ZFPM1
Function transcription regulatory region DNA binding
Related Protein KLF4; CDK5RAP2; NKX3; IKZF2; YAP1; SMAD3; FOXA2; GATA6; GABPB2; NKX2-5
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein SOX17; FOXF2; GATA5; GATA1; CSRNP1; ESRRG; FOXF1; ETV5; LMO2; STAT3
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein RCOR1; MXD1; ZBTB20; BACH1; TGIF1; MZF1; TBX15; IFI16; BATF3; BHLHE40

Interacting Protein

REST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REST here. Most of them are supplied by our site. Hope this information will be useful for your research of REST.
SMARCA4; SMARCC2; SMARCE1

REST Related Articles

Elbeshehy, EKF; Metwali, EMR; et al. Antiviral activity of Thuja orientalis extracts against watermelon mosaic virus (WMV) on Citrullus lanatus. SAUDI JOURNAL OF BIOLOGICAL SCIENCES 22:211-219(2015).
Diaz-Torne, C; Perez-Herrero, N; et al. New medications in development for the treatment of hyperuricemia of gout. CURRENT OPINION IN RHEUMATOLOGY 27:164-169(2015).