REST

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REST

Official Full Name RE1-silencing transcription factor
Background This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
Synonyms REST; RE1-silencing transcription factor; XBR; NRSF; repressor binding to the X2 box; neural-restrictive silencer factor; neuron restrictive silencer factor; RE1-silencing transcription factor variant E1a/E2/E4; RE1-silencing transcription factor variant E1a/E2/E3/E5; RE1-silencing transcription factor variant E1b/E2/E3/E5; RE1-silencing transcription factor variant E1c/E2/E3/E5; RE1-silencing transcription factor variant E1a/E2/E3/E4c; RE1-silencing transcription factor variant E1c/E2g/E3/E4; RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i; RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i; RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4; RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human REST-2417HCL Recombinant Human REST 293 Cell Lysate HEK293 N/A
    Mouse REST-14084M Recombinant Mouse REST Protein Mammalian Cell His
    Rat REST-5000R Recombinant Rat REST Protein Mammalian Cell His

    REST involved in several pathways and played different roles in them. We selected most pathways REST participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with REST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells FZD3; INHBA; REST; HRAS; SKIL; BMPR1A; ID3; PCGF1; SMAD3; PIK3CA
    Huntingtons disease PLCB4; POLR2G; GPX1; COX7A2; NDUFA4L2; POLR2D; COX7B; POLR2J2; DCTN1; NDUFS2

    REST has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by REST itself. We selected most functions REST had, and list some proteins which have the same functions with REST. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding CUX1; RNF2; RAG2; EZH2; TLE1; ANKRD17; SP100; HINFP; FANCM; CIC
    core promoter binding KDM3A; FOXO3; INSM1B; NOTCH1; PSPC1; MTF1; CRY1; KLF4; MED1; HDAC6
    core promoter sequence-specific DNA binding MTA1; SOX4; TP53; PDX1; REST; SOX9; KLF10; GATA3; ESR2; NR4A3
    metal ion binding KCNIP1B; PHLPP1; WT1B; PDE4C; PCGF5B; METAP2B; ZBBX; ZFP451; PPAT; TIMM8B
    outward rectifier potassium channel activity REST; KCNB1; KCNA5; KCNK1A; KCNK5B; KCNK2; KCNK18; KCNK2B; KCNQ1
    protein binding FAT4; OSBPL1A; NF1; UBA52; ZNF148; FCGR2A; DLA; EIF3C; PAFAH1B1; EVI5
    transcription factor activity, sequence-specific DNA binding CARF; GATA1A; ZNF396; ZNF621; KAT7B; ZNF227; ZSCAN4D; DLX3; ATF1; ZFP28
    transcription factor binding BPTF; DDX3X; ZFPM2; HMGB1; STAT3; MAFB; KAT2A; GTF2A2; HMGA1; FOXO1
    transcription regulatory region DNA binding ZFP161; TFEB; PHB; PAX2; ZFP335; FOXC2; TBL1X; RREB1; SREBF1; NKX2-1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding FOXF1; NR1I2; CREBBP; REST; TRP53; IRF2; BARX1; MSGN1; MAFA; CREB3L3
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NR2C1; SNAI1; AEBP2; GZF1; PRDM5; NFATC4; ASCL1; SPI1; SP3; PROX1B

    REST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REST here. Most of them are supplied by our site. Hope this information will be useful for your research of REST.

    SMARCA4; SMARCC2; SMARCE1

    Elbeshehy, EKF; Metwali, EMR; et al. Antiviral activity of Thuja orientalis extracts against watermelon mosaic virus (WMV) on Citrullus lanatus. SAUDI JOURNAL OF BIOLOGICAL SCIENCES 22:211-219(2015).
    Diaz-Torne, C; Perez-Herrero, N; et al. New medications in development for the treatment of hyperuricemia of gout. CURRENT OPINION IN RHEUMATOLOGY 27:164-169(2015).

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