ring1
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  • Official Full Name
  • ring finger protein 1
  • Background
  • This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a;zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional;repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the;polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It;interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region,;where it is contiguous with the RING finger genes FABGL and HKE4.
  • Synonyms
  • RING1; ring finger protein 1; E3 ubiquitin-protein ligase RING1; RNF1; polycomb complex protein RING1; really interesting new gene 1 protein; RING1A
Cat.#:RING1-2311HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RING1, His-tagged
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Cat.#:RING1-29982THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RING1
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Cat.#:RING1-14237MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RING1 Protein
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Cat.#:RING1-5052RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RING1 Protein
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Cat.#:RING1-3898RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RING1 Protein, His-tagged
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Cat.#:RING1-2337HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RING1 293 Cell Lysate
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Involved Pathway

RING1 involved in several pathways and played different roles in them. We selected most pathways RING1 participated on our site, such as Cellular Senescence, Cellular responses to stress, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RING1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular Senescence
PHC3; CBX6; RBBP7; CDKN2A; HMGA1; RING1; HIST4H4; EHMT2; E2F3; POT1
Cellular responses to stress
EED; TNIK; HSPA7; BMI1A; RBBP7; HIF1AN; DYNLL2; EGLN1B; DNAJB6; NUP50
Delta-Notch Signaling Pathway
ASCL1A; TUBB3; YY1A; NOV; APPA; MAGEA1; RING1; CNTN1; WDR12; HES6
Metabolism of proteins
APEH; IGFBP1B; TRAPPC9; NOP56; LDHD; SPON1A; ST3GAL3A; GALNT13; IGFBP6B; THSD7A
Oxidative Stress Induced Senescence
CBX8B; BMI1A; PHC2; RNF2; PHC1; KDM6B; TNIK; CBX6A; SUZ12B; SUZ12
Post-translational protein modification
DNAJC24; DPH5; MAN1A2; MUC4; TRAPPC6B; EIF5A; SPON1; ST8SIA3; ARSK; MCFD2
SUMO E3 ligases SUMOylate target proteins
PHC1; SCMH1; CBX4; PHC3; EID3; NSMCE2; PHC2; SMC6; CBX8; RING1
SUMOylation
SENP1; PHC2; CBX8; SMC6; SAE1; PHC3; SMC5; NSMCE4A; UBA2; PHC1

Protein Function

RING1 has several biochemical functions, for example, chromatin binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RING1 itself. We selected most functions RING1 had, and list some proteins which have the same functions with RING1. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein PHF21A; POLR2B; TRP53; TOP2B; GATA2B; SP140; STAT5B; ZNF143; TCF7L1B; GATA1A
Function ligase activity
Related Protein GLULA; WWP1; RNF114; ATG10; MARCH2; TRIM2; ITCHA; HERC6; MKRN3; BIRC3
Function protein binding
Related Protein IFI16; TSC1; ANTXR1; MAK; DDX20; USP12; PRKAR2A; SPEF2; SIP1; GGA1
Function ubiquitin-protein transferase activator activity
Related Protein FBXW7; AUP1; CBX8; UBE2L3; RING1
Function zinc ion binding
Related Protein VPS41; DNAJC24; ALKBH8; LMX1A; LNX2B; PGLYRP3; NR3C2; ADAM1B; ZSWIM4; TAF3

Interacting Protein

RING1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RING1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RING1.
BMI1; CBX8

RING1 Related Articles

Pemberton, H; Anderton, E; et al. Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts. GENOME BIOLOGY 15:-(2014).
Endoh, M; Endo, TA; et al. Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. DEVELOPMENT 135:1513-1524(2008).