Human RING1 Knockdown Cell Lysate

• Cat.No.: RING1-289HKCL
• Product Overview: WB-validated RING1 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 42 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg RING1 KD HeLa cell lysate
• Protein Families: Druggable Genome, Transcription Factors
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: RING1 ring finger protein 1 [ Homo sapiens (human) ]
• Official Symbol: RING1
• Synonyms: RING1; ring finger protein 1; E3 ubiquitin-protein ligase RING1; RNF1; polycomb complex protein RING1; really interesting new gene 1 protein; RING1A
• Gene ID: 6015
• mRNA Refseq: NM_002931
• Protein Refseq: NP_002922
• MIM: 602045
• UniProt ID: Q06587