rln2
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  • Official Full Name
  • relaxin 2
  • Background
  • Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
  • Synonyms
  • RLN2; relaxin 2; H2; RLXH2; bA12D24.1.1; bA12D24.1.2; relaxin 2 (H2); prorelaxin H2; relaxin H2; relaxin, ovarian, of pregnancy; Relaxin B chain; Relaxin A chain; OTTHUMP00000021027; OTTHUMP00000196912
Cat.#:RLN2-172HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Relaxin 2
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Cat.#:RLN2-173HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Relaxin 2
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Cat.#:RLN2-220HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RLN2 Protein, His-tagged
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Cat.#:RLN2-30491THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RLN2
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Cat.#:RLN2-7081HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RLN2, His-tagged
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Cat.#:RLN2-3904RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RLN2 Protein, His-tagged
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Involved Pathway

RLN2 involved in several pathways and played different roles in them. We selected most pathways RLN2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RLN2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)
APLN; GPR31B; OXER1; ADRB2; PROK2; OPN1SW1; ADRa1A; PPY; PNOCB; TAC1
G alpha (s) signalling events
PDE10A; ADM2A; CRHB; ADCYAP1; SCT; ADRB3; CGA; RLN3A; ADCYAP1R1; CALCB
GPCR downstream signaling
CCR9; PROKR1A; LTB4R; NPFF; MCF2L; S1PR3; OR7D2; GPR17; TAC2; TAS2R7
GPCR ligand binding
PMCH; CXCL13; CALCRL; TAS2R3; ADRA2B; CCL27; OXGR1A.1; GRP; CASR; PTHRP2
Peptide ligand-binding receptors
SSTR1; HEBP1; ACKR4; ZFPM2B; NMB; INSL3; SSTR5; CX3CR1; PRLH; NTS
Relaxin receptors
RLN3A; INSL3; RLN2; RXFP2; RLN3; INSL5
Signal Transduction
GPR18; KISS1; SDR9C7; SDR16C5; TAC3; NPFF; RDH13; GUCA1E; ARHGAP19; PDK2
Signaling by GPCR
OR4D2; PROKR1; OR2AP1; S1PR5B; TAS2R7; KEL; RCA2.1; OXER1; OR7D2; RAMP3

Protein Function

RLN2 has several biochemical functions, for example, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RLN2 itself. We selected most functions RLN2 had, and list some proteins which have the same functions with RLN2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein CRH; UTS2A; GCG; INSL5; POMCB; INSL3; INSL5A; CHGB; TTR; LHB

RLN2 Related Articles

Arroyo, JI; Hoffmann, FG; et al. Evolution of the Relaxin/Insulin-Like Gene Family in Anthropoid Primates. GENOME BIOLOGY AND EVOLUTION 6:491-499(2014).
Rocha, FG; Slavin, TP; et al. Genetic associations of relaxin: preterm birth and premature rupture of fetal membranes. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 209:-(2013).