RLN2
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Official Full Name
relaxin 2
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Overview
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. -
Synonyms
RLN2; relaxin 2; H2; RLXH2; bA12D24.1.1; bA12D24.1.2; relaxin 2 (H2); prorelaxin H2; relaxin H2; relaxin, ovarian, of pregnancy; Relaxin B chain; Relaxin A chain; OTTHUMP00000021027; OTTHUMP00000196912;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Pig
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | RLN2-30491TH | Recombinant Human RLN2 | E.coli | N/A |
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| Human | RLN2-173H | Recombinant Human Relaxin 2 | E.coli | N/A |
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| Human | RLN2-172H | Recombinant Human Relaxin 2 | E.coli | N/A |
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| Human | RLN2-220H | Recombinant Human RLN2 Protein, His-tagged | E.coli | His |
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| Human | RLN2-7081H | Recombinant Human RLN2, His-tagged | E.coli | His | 25-185aa |
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| Human | RLN2-6180H | Recombinant Human RLN2 Protein (Val23-Cys185), N-His tagged | E.coli | N-His | Val23-Cys185 |
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| Rhesus Macaque | RLN2-3904R | Recombinant Rhesus monkey RLN2 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | RLN2-3721R | Recombinant Rhesus Macaque RLN2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | RLN2-3721R-B | Recombinant Rhesus Macaque RLN2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Pig | RLN2-2672P | Recombinant Pig RLN2 Protein, His-tagged | E.coli | N-His | Gln25-Cys182 (Accession # P01348) |
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- Involved Pathway
- Protein Function
- Interacting Protein
- RLN2 Related Articles
RLN2 involved in several pathways and played different roles in them. We selected most pathways RLN2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RLN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | NMB;CCRL2;OPN1SW1;FPR-RS6;CX3CR1;DRD3;TAAR1;CYSLTR1;PROKR1A |
| G alpha (s) signalling events | GHRH;NPSR1;CRH;RAMP1;DRD5;ADCYAP1R1;RLN3A;CRHR2;ADM2 |
| GPCR downstream signaling | PTHRP2;OPN1MW;OR52B4;TRPC3;ARHGAP4;ABHD12;RGS11;LPAR1;QRFPR |
| GPCR ligand binding | ADM2A;GPR39;ADORA3;CASR;GHRH;NTS;NMUR1;EMR1;SSTR2 |
| Peptide ligand-binding receptors | SST1.1;PPY;HEBP1;APLN;PROKR1;NPB;HCRT;TRH;QRFPR |
| Relaxin receptors | RLN3;INSL5;RLN3A;RLN2;RXFP2;INSL3 |
| Signal Transduction | SOX9A;AES;APLNR;ANXA1B;TLE4;IGF2BP1;RHOU;TAC3;LRP12 |
| Signaling by GPCR | UTS2D;OPN4A;VIP2;EMR4;GHRH;OXGR1A.2;PTHLH;PTH2;ARHGEF3 |
RLN2 has several biochemical functions, for example, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RLN2 itself. We selected most functions RLN2 had, and list some proteins which have the same functions with RLN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | INS-IGF2;RLN3A;RETN;UTS1;PRLH;HAMP;FNDC5B;PRL3B1;IGF2B |
RLN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RLN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RLN2.
- Q&As
- Reviews
Q&As (5)
Ask a questionRLN-2 induces vasodilation by activating nitric oxide (NO) signaling pathways, promoting smooth muscle relaxation and increased blood flow.
RLN-2 has immunomodulatory effects, influencing cytokine production, immune cell migration, and contributing to the regulation of inflammatory responses.
RLN-2 exerts anti-fibrotic effects by inhibiting myofibroblast differentiation, reducing collagen deposition, and modulating fibrotic signaling pathways.
RLN-2 inhibits collagen synthesis and enhances collagen degradation by modulating the activity of enzymes involved in collagen turnover.
RLN-2 promotes extracellular matrix remodeling by upregulating matrix metalloproteinases (MMPs) and inhibiting tissue inhibitors of metalloproteinases (TIMPs).
Customer Reviews (3)
Write a reviewSuperior quality—this protein is a must-have in our lab for consistent outcomes.
The quality control is evident in the data precision we achieve.
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