rnf14
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  • Official Full Name
  • ring finger protein 14
  • Background
  • The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.
  • Synonyms
  • RNF14; ring finger protein 14; E3 ubiquitin-protein ligase RNF14; ARA54; HFB30; TRIAD2; Androgen receptor associated protein 54; Androgen receptor-associated protein 54; ARA 54; E3 ubiquitin protein ligase RNF14; FLJ26004; HFB 30; HRIHFB2038; RNF 14; RNF14_HUMAN; TRIAD 2; Triad2 protein; OTTHUMP00000160065; OTTHUMP00000160066
Cat.#:RNF14-686HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RNF14 Protein, MYC/DDK-tagged
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Cat.#:RNF14-14303MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RNF14 Protein
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Cat.#:RNF14-3930RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RNF14 Protein, His-tagged
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Cat.#:RNF14-2332CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RNF14
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Cat.#:RNF14-319ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RNF14
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Cat.#:RNF14-2296HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RNF14 293 Cell Lysate
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Involved Pathway

RNF14 involved in several pathways and played different roles in them. We selected most pathways RNF14 participated on our site, such as Adaptive Immune System, Androgen receptor signaling pathway, Antigen processing: Ubiquitination &, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF14 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
KIF4; STIM1B; KIF20A; KIF4A; KLHL21; CD200R4; RNF111; LILRB1; ASB2; KIF3C
Androgen receptor signaling pathway
ETV5A; RHOB; NR2C2; JUN; GNB2L1; PIAS3; KAT7B; CARM1; PATZ1; KDM1A
Antigen processing: Ubiquitination &
TPP2; BLMH; ASB18; LTN1; GAN; ASB11; RNF4; RNF220; CMTM2A; DTX3L
Proteasome degradation
RNF123; TRIM39; SH3RF1; LTN1; RNF25; CMTM2A; ATG7; TRIM41; LRSAM1; TRAF7
Class I MHC mediated antigen processing &
CYBA; ERAP1; CD207; UBE2J2; CMTM2A; HUWE1; DZIP3; RNF41; TPP2; RNF182
presentation
SPSB4; RNF14; TRIM39; FBXO3; FBXO27; KLHL20; UBR1; MKRN1; DZIP3; UBE2V2
Immune System
ICAM4; DEFB119; TXNIPB; CTSD; PCBP2; USP18; ERAP2; NOD1; GZMM; TRIM17

Protein Function

RNF14 has several biochemical functions, for example, androgen receptor binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF14 itself. We selected most functions RNF14 had, and list some proteins which have the same functions with RNF14. You can find most of the proteins on our site.
Function
Related Protein
Function androgen receptor binding
Related Protein CDK7; FOXH1; DDX5; BRCA1; RNF14; NCOA4; FHL2; RNF6; TGFB1I1; KAT5
Function ligase activity
Related Protein RFWD3; RNF180; RLIM; CBLL1; DTX3L; MKRN2; RFFL; HECTD3; EGR2; RNF13
Function protein binding
Related Protein GIMAP7; CDK2AP1; ADRA2A; C1QBP; FAM65B; MT2A; FRMPD2; EMX2; LNPEP; RABL2A
Function transcription coactivator activity
Related Protein MED23; GATA4; GTF2A1; RIPK3; KAT6A; LPIN2; TFDP1B; SUB1; TFDP1A; RXRB
Function ubiquitin conjugating enzyme binding
Related Protein DCUN1D2; RNF14; RNF144AA; FOXL2; RNF40; UBE2V1; DCUN1D2A; SIAH2; DCUN1D3; TCHP
Function ubiquitin protein ligase activity
Related Protein RNF14; RNF25; ANKIB1; UBE2B; ARIH1L; PJA1; PELI1; PDZRN3B; MSL2; CBL
Function ubiquitin-like protein transferase activity
Related Protein UBL4A; ATG3; ARIH1; RNF14; ATG16L1; RNF139
Function zinc ion binding
Related Protein LPP; NR1D2; KDM5A; CAR3; TAB3; C6AST4; DTX3L; TRIM32; RXRG; TRIM35-29

Interacting Protein

RNF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF14.
UBE2D1; UBE2D4; DACH1; AR; HNF1A; UBE2E1; UBE2D3; UBE2D2; UBE2V1; FAM46A