RNF14 Protein, ring finger protein 14


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Official Full Name ring finger protein 14
Background The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.
Synonyms RNF14; ring finger protein 14; E3 ubiquitin-protein ligase RNF14; ARA54; HFB30; TRIAD2; Androgen receptor associated protein 54; Androgen receptor-associated protein 54; ARA 54; E3 ubiquitin protein ligase RNF14; FLJ26004; HFB 30; HRIHFB2038; RNF 14; RNF14_HUMAN; TRIAD 2; Triad2 protein; OTTHUMP00000160065; OTTHUMP00000160066
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF14-2296HCL Recombinant Human RNF14 293 Cell Lysate HEK293 N/A
    Human RNF14-686H Recombinant Human RNF14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse RNF14-14303M Recombinant Mouse RNF14 Protein Mammalian Cell His
    Rhesus Macaque RNF14-3930R Recombinant Rhesus monkey RNF14 Protein, His-tagged Mammalian Cell His
    Chicken RNF14-2332C Recombinant Chicken RNF14 Mammalian Cell His
    Zebrafish RNF14-319Z Recombinant Zebrafish RNF14 Mammalian Cell His

    RNF14 involved in several pathways and played different roles in them. We selected most pathways RNF14 participated on our site, such as Adaptive Immune System, Androgen receptor signaling pathway, Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CLEC2G; KIF2C; Siglece; PVRL2L; AF251705; SPSB1; CD300A; ITK; TPP2; KIF4A
    Androgen receptor signaling pathway CTNNB1; RAD54L2; RANBP9; JUN; PNRC1; MYST2; SMARCE1; POU2F1B; RAD9A; HMGB2A
    Antigen processing: Ubiquitination &amp LRR1; UBE2V1; UBE2E3; KLHL20; BLMH; SPSB2; WSB1; ASB8; TRAF7; UBE2V2
    Proteasome degradation PJA2; ASB6; FBXO44; UBE2U; ASB3; HECTD3; ASB17; RNF4; RNF34; DTX3L
    Class I MHC mediated antigen processing &amp LRRC41; LRR1; NPEPPS; UBE2L6; ERAP1; VPRBP; SEC61B; RNF41; ASB7; CMTM2A
    presentation RBCK1; SEC23A; RNF14; TRIM63; RNF34; MKRN1; PJA2; PJA1; ASB8; TRIM50
    Immune System ADAR; CISH; CFHL4; ALCAMB; DEFB119; HBL3; NA; FCN1; RNF41; CD200

    RNF14 has several biochemical functions, for example, androgen receptor binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF14 itself. We selected most functions RNF14 had, and list some proteins which have the same functions with RNF14. You can find most of the proteins on our site.

    Function Related Protein
    androgen receptor binding EP300; RNF6; CCNE1; PKN1; RNF14; SMARCA4; KDM1A; NCOA1; TGFB1I1; KDM3A
    ligase activity TTLL6; TRIM28; UBOX5; TRIM21; RNF217; MARCH10; TRIM27; RNF144B; PCXA; SHRPRBCK1R
    protein binding CNEP1R1; KCTD6; SGPL1; ZNF397; IL2RG; PHF1; FBL; DNM3; C16orf72; CKM
    transcription coactivator activity CCNE1; TADA2B; HINFP; ABRA; UBE2L3; TFAP2B; HAND1; THRAP3; CDK7; SUB1A
    ubiquitin conjugating enzyme binding DCUN1D2B; SIAH2; ANKIB1; GRIK2; ARIH2; RNF144AB; DCUN1D2; DCUN1D1; TOLLIP; DCUN1D2A
    ubiquitin protein ligase activity HECTD1; SYVN1; MED21; UBE2B; TOPORS; TRIM37; UBE2R2; UHRF2; RABGEF1; RNF122
    ubiquitin-like protein transferase activity RNF14; UBL4A; ARIH1; ATG16L1; RNF139; ATG3
    zinc ion binding TRIM35-1; ZNF346; SHPRH; LPXN; ZDHHC19; TRIM8; RGN; ZFAND4; ZNF330; ZNF331

    RNF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF14.

    UBE2D1; UBE2D4; DACH1; AR; HNF1A; UBE2E1; UBE2D3; UBE2D2; UBE2V1; FAM46A

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