RNF25
-
Official Full Name
ring finger protein 25 -
Overview
The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. -
Synonyms
RNF25;ring finger protein 25;E3 ubiquitin-protein ligase RNF25;AO7;FLJ13906;ring finger protein AO7
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- His
- DDK
- Myc
- Non
- Flag
- Avi
- Fc
Involved Pathway
RNF25 involved in several pathways and played different roles in them. We selected most pathways RNF25 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | KIR2DS2,ITPR2,CTSB,TPP2,PIK3AP1,LILRB1,SEC24A,THEM4,FBXO3,RAPGEF3 |
| Proteasome degradation | FBXO3,UBR1,BLMH,TRIM39,ASB2,TRIM41,WWP1,ASB9,SH3RF1,UBE2L6 |
| TNF-alpha/NF-kB Signaling Pathway | PEG3,NKIRAS2,KPNA6,DDX3X,TNIP1,CAPN3,TIFA,PAPOLA,COMMD1,NKIRAS1 |
| presentation | RNF34,DZIP3,ASB6,SPSB4,VPRBP,RNF14,LRSAM1,RNF4,PJA2,ASB3 |
| Antigen processing: Ubiquitination & | LRSAM1,ASB4,ASB3,RNF111,RNF138,LTN1,LRRC41,TRIM39,RNF123,RNF144B |
| Tryptophan metabolism | HAAO,AOX4,ALDH1B1,AOX2P,OGDHA,OGDHL,KYNU,HADHAB,AOX3L1,TPH1B |
| Immune System | TRIM5,DHX9,SPSB2,BTR18,DDX41,TRIM41,ABI2,TRIM62,ARIH1,WSB1 |
| Class I MHC mediated antigen processing & | UBR1,UBE2L6,STUB1,CD207,TRIM41,ASB6,FBXO27,TPP2,UBE2F,TRIM11 |
Protein Function
RNF25 has several biochemical functions, for example, NF-kappaB binding,ligase activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF25 itself. We selected most functions RNF25 had, and list some proteins which have the same functions with RNF25. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | MARCH6,ZNF738,RNF5,UBE2L3,PRP19,UBE2T,HERC2,TRIM5,ANKIB1A,KLHL20 |
| zinc ion binding | ZCCHC18,ZFYVE1,RBM5,FHL1,ADAM10B,CAPNS2,PDLIM3B,RNF141,NUP153,TRIM35-39 |
| NF-kappaB binding | HSPA6,RELA,SNAI1A,RPS3,ANXA4,NFKBIA,FOXP3,COMMD6,COMMD7,CDK5RAP3 |
| ubiquitin protein ligase activity | MARCH8,RNF19A,RNF126,UBR3,RNF115,RNF144AB,RNF152,MYLIP,UBE2A,UBE2J1 |
| ligase activity | SMURF1,TRIM68,RNF19B,PIAS4,MYLIPA,BTR22,RNF126,HUWE1,RNF114,RNF144B |
Interacting Protein
RNF25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF25 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF25.
UBE2D1;UBE2E1;UBE2D3;UBE2D2;UBE2E3;UBE2D4;UBE2L6;TRIM27;UBE2U;UBE2E2
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