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RNF7

  • Official Full Name

    ring finger protein 7

  • Overview

    The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms

    RNF7; ring finger protein 7; SAG; ROC2; CKBBP1; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2; RING-box protein 2; Rbx2; CKII beta-binding protein 1; Regulator of cullins 2; Sensitive to apoptosis gene protein; OTTHUMP00000180644; OTTHUMP00000180645; zinc RING finger protein SAG;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RNF7-2286H Recombinant Human RNF7, His-tagged E.coli His 136aa
Human RNF7-670H Recombinant Human RNF7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RNF7-2272HCL Recombinant Human RNF7 293 Cell Lysate HEK293 N/A
Human RNF7-1506H Recombinant Human RNF7 Protein (2-113 aa), His-tagged Yeast His 2-113 aa
Human RNF7-780H Recombinant Human RNF7 Protein (2-113 aa), GST-tagged E.coli GST 2-113 aa
Mouse RNF7-14354M Recombinant Mouse RNF7 Protein Mammalian Cell His
Mouse RNF7-7690M Recombinant Mouse RNF7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Rnf7-5560M Recombinant Mouse Rnf7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RNF7-7690M-B Recombinant Mouse RNF7 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RNF7-3947R Recombinant Rhesus monkey RNF7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RNF7-3764R Recombinant Rhesus Macaque RNF7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RNF7-3764R-B Recombinant Rhesus Macaque RNF7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish RNF7-2057Z Recombinant Zebrafish RNF7 Mammalian Cell His
Chicken RNF7-2963C Recombinant Chicken RNF7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RNF7 Related Articles

RNF7 involved in several pathways and played different roles in them. We selected most pathways RNF7 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisSOCS1;UBE2NA;RHOBTB1;ANAPC1;CDC26;WWP2;UBE2H;UBE2A;CUL4B

RNF7 has several biochemical functions, for example, NEDD8 transferase activity, copper ion binding, cullin family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF7 itself. We selected most functions RNF7 had, and list some proteins which have the same functions with RNF7. You can find most of the proteins on our site.

Function Related Protein
NEDD8 transferase activityRBX1;RNF7;UBE2M;UBE2F
copper ion bindingMOXD1;MT3;HEPHL1A;TYRP1B;LOXL3B;CUTC;LOXL1;S100V2;CCS
cullin family protein bindingDCUN1D2B;DCUN1D3;ANAPC11;CCDC22;TCHP;DCUN1D4;PARK2;RNF7;DCUN1D5
protein bindingHSFY1;OTUB1;MIEN1;PAFAH1B1;CCDC9;CCT5;GPSM1;CARD10;BIRC3
ubiquitin protein ligase activityCBL;PDZRN4;LRSAM1;FANCF;CBLC;UHRF2;MED20;RNF25;SIAH1A
zinc ion bindingCPA6;LIMK1;LHX2B;TRIM10;SIAH2L;ISL2;RNF130;RXRA;ZCCHC17

RNF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF7.

CUL5; IKBKG; vif; RAB40C; ASB12; ASB2; ASB7; ASB6; ASB1; UBE2D1

Zhou, WH; Xu, J; et al. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. ONCOTARGET 5:6746-6755(2014).
Sahun, I; Marechal, D; et al. Cognition and Hippocampal Plasticity in the Mouse Is Altered by Monosomy of a Genomic Region Implicated in Down Syndrome. GENETICS 197:899-912(2014).
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