|Official Full Name||roundabout, axon guidance receptor, homolog 3 (Drosophila)|
|Background||This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and;axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT;proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate;myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis.;This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin;(Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2,;and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene;regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete;failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result;in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by;congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon;tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been;experimentally validated.|
|Synonyms||ROBO3; roundabout, axon guidance receptor, homolog 3 (Drosophila); HGPPS, horizontal gaze palsy with progressive scoliosis , roundabout (axon guidance receptor, Drosophila) homolog 3; roundabout homolog 3; FLJ21044; HGPS; RBIG1; HGPPS; RB inhibiting gene 1; Rbig 1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3 protein; Roundabout axon guidance receptor homolog 3; Roundabout like protein 3; roundabout-like protein 3|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ROBO3 involved in several pathways and played different roles in them. We selected most pathways ROBO3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROBO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Axon guidance||ITGB1B.1; GDNF; RHOC; MAPK1; DUSP2; SEMA4C; CSNK2A2; DPYSL3; WDR83; GNAI2|
ROBO3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ROBO3 itself. We selected most functions ROBO3 had, and list some proteins which have the same functions with ROBO3. You can find most of the proteins on our site.
ROBO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROBO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROBO3.