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ROBO3

  • Official Full Name

    roundabout, axon guidance receptor, homolog 3 (Drosophila)

  • Overview

    This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and;axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT;proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate;myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis.;This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin;(Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2,;and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene;regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete;failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result;in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by;congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon;tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been;experimentally validated.
  • Synonyms

    ROBO3; roundabout, axon guidance receptor, homolog 3 (Drosophila); HGPPS, horizontal gaze palsy with progressive scoliosis , roundabout (axon guidance receptor, Drosophila) homolog 3; roundabout homolog 3; FLJ21044; HGPS; RBIG1; HGPPS; RB inhibiting gene 1; Rbig 1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3 protein; Roundabout axon guidance receptor homolog 3; Roundabout like protein 3; roundabout-like protein 3;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ROBO3-896H Recombinant Human ROBO3 Mammalian Cell His
Human ROBO3-3998H-B Recombinant Human ROBO3 Protein Pre-coupled Magnetic Beads HEK293
Human ROBO3-3998H Recombinant Human ROBO3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ROBO3-9041Z Recombinant Zebrafish ROBO3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ROBO3 involved in several pathways and played different roles in them. We selected most pathways ROBO3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROBO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceABL1;SCN2B;DPYSL5B;UNC5D;SCN9A;EPHB4A;PAK1;SEMA5A;CAP2

ROBO3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ROBO3 itself. We selected most functions ROBO3 had, and list some proteins which have the same functions with ROBO3. You can find most of the proteins on our site.

Function Related Protein

ROBO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROBO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROBO3.

APOA1

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