rps3
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  • Official Full Name
  • ribosomal protein S3
  • Background
  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
  • Synonyms
  • RPS3; ribosomal protein S3; S3; 40S ribosomal protein S3; IMR-90 ribosomal protein S3;
Cat.#:RPS3-2420HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ribosomal Protein S3
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Cat.#:RPS3-2421HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ribosomal Protein S3, His-tagged
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Cat.#:RPS3-29970THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS3
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Cat.#:RPS3-30468THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS3 protein, His-tagged
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Cat.#:RPS3-480HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS3, GST-tagged
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Cat.#:RPS3-6890HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ribosomal Protein S3, His-tagged
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Cat.#:RPS3-14489MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RPS3 Protein
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Cat.#:RPS3-5168RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPS3 Protein
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Cat.#:RPS3-4025RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RPS3 Protein, His-tagged
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Cat.#:RPS3-2532CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RPS3
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Cat.#:RPS3-11372ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPS3
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Cat.#:RPS3-563HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human RPS3 lysate
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Involved Pathway

RPS3 involved in several pathways and played different roles in them. We selected most pathways RPS3 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome
RPS4Y2; RPL34-PS1; RPS14; RPS24; RPL39; MRPL18; MRPS11; RPL13A; RPS11; RPS8

Protein Function

RPS3 has several biochemical functions, for example, NOT DNA N-glycosylase activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS3 itself. We selected most functions RPS3 had, and list some proteins which have the same functions with RPS3. You can find most of the proteins on our site.
Function
Related Protein
Function NOT DNA N-glycosylase activity
Related Protein RPS3
Function DNA binding
Related Protein ZBTB1; ZNF524; EMX3; XRCC5; HIST1H2AD; RPAP1; POLA2; HINFP; NABP2; AHRRB
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein NEIL1; HMGA1-RS1; HMGA1B; RPS3; ALKBH1; NEIL2; NTHL1; APLF; APEX1; NEIL3
Function Hsp70 protein binding
Related Protein DNAJB2; STUB1; DNAJC10; TSACC; PACRG; DNAJC2; ERN1; STIP1; ST13; DNAJB1
Function Hsp90 protein binding
Related Protein NPAS2; PACRG; ERBB2; PPID; FKBP6; HDAC6; NASP; RPS3; EIF2AK3; UNC45B
Function NF-kappaB binding
Related Protein PSMA6; EP300; ANXA4; SNAI1A; BCL10; RPS3; HIF1AN; RELA; FOXP3; AP1S2
Function RNA binding
Related Protein RBM14; ZBP1; PUS7L; AGO3B; PAPOLG; CPEB1B; PSMA1; NSUN5B; PPP1R8; CNOT4B
Function SUMO binding
Related Protein USP25; RPS3; USPL1; HERC2; TOLLIP; TDG; CBX4; PML
Function damaged DNA binding
Related Protein NEIL3; CRY2; NEIL2; RAD23AB; XPA; CREBBP; OGG1; RPA2; RAD1; XRCC6
Function endodeoxyribonuclease activity
Related Protein MRE11A; DNASE1L3; ERCC4; MBD4; ERCC5; DNASE2A; DNASE1L1; DNASE1; DNASE1L2; APEX1
Function enzyme binding
Related Protein TTN; RCOR1; CDK19; POLB; JUND; BRCA1; DNM2; HIST1H2AI; PUS7; PLSCR4
Function iron-sulfur cluster binding
Related Protein ISCUB; PROZA; NUBP1; FDX1B; EXO5; NFS1; DPYDA.1; RTEL1; NDUFS1; PRIM2
Function kinase binding
Related Protein TRIP6; PRPSAP1; MIDN; RPS3; PRKAA1; PER1; TRADD; C2orf44; TENC1; PPP2R5A
Function mRNA binding
Related Protein SNRPC; RBM38; RBM25; RPS26L; NUDT16; RPS13; CELF3; SSB; MECP2; CSTF3
Function microtubule binding
Related Protein JAKMIP1; KIF17; KIF7; LC3; NME8; NDEL1; SGIP1; MAST2; RPS3; NDEL1B
Function oxidized purine DNA binding
Related Protein OGG1; RPS3
Function oxidized purine nucleobase lesion DNA N-glycosylase activity
Related Protein OGG1; RPS3
Function oxidized pyrimidine DNA binding
Related Protein RPS3
Function poly(A) RNA binding
Related Protein EXOSC6; MRM1; ZC3H10; EIF1B; SRSF12; C14orf21; MTERF; PEG10; ISY1; PURG
Function protein binding
Related Protein ERGIC2; C2orf62; ATP6V1F; COPS6; KRT79; SPP1; MYO18A; PBXIP1; EEA1; MGARP
Function protein kinase A binding
Related Protein AKAP12; MYRIP; Akap2; AKAP7; AKAP14; AKAP17A; AKAP13; AKAP12B; AKAP4; AKAP5
Function protein kinase binding
Related Protein GRB7; CDC25A; CDK5RAP3; DPYSL2; RACGAP1; BAG5; TELO2; CDK5; Fert2; AP2A2
Function small ribosomal subunit rRNA binding
Related Protein RPS3; MRPS6; RPS14; NSUN4; CIRBP; RPS13; UTP23; MRPS11
Function structural constituent of ribosome
Related Protein RPL26L1; RPS8; RSL24D1; MRPS12; MRPL35; MRPS17; RPLP2L; RPS8B; RPL35A; RPL10
Function supercoiled DNA binding
Related Protein HMGB1; PSIP1; HMGB2; RPS3
Function transcription factor binding
Related Protein HDAC9; ARID5A; KAT2B; ZFPM2; PPP1R13L; HDAC7; BCL3; UBA2; SMAD2; TMEM173
Function tubulin binding
Related Protein MTAP4; IFT81; FYN; RPS3; RABGAP1; STMN3; STMN2A; TPPP3; AGTPBP1; STMN2
Function ubiquitin-like protein conjugating enzyme binding
Related Protein RPS3; RNF185; PARK7

Interacting Protein

RPS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS3.
RELA; MDM2; NFKBIA

RPS3 Related Articles

Ahn, EH; Kim, DW; et al. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. FREE RADICAL BIOLOGY AND MEDICINE 55:36-45(2013).
Choi, SH; Kim, SY; et al. Immunohistochemical studies of human ribosomal protein s3 (rpS3). JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 39:208-215(2006).
HANDA, H; GUALBERTO, JM; et al. CHARACTERIZATION OF THE MITOCHONDRIAL ORFB GENE AND ITS DERIVATIVE, ORF224, A CHIMERIC OPEN READING FRAME SPECIFIC TO ONE MITOCHONDRIAL GENOME OF THE POLIMA MALE-STERILE CYTOPLASM IN RAPESEED (BRASSICA-NAPUS L). CURRENT GENETICS 28:546-552(1995).