rnf5
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  • Official Full Name
  • ring finger protein 5, E3 ubiquitin protein ligase
  • Background
  • The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.
  • Synonyms
  • RNF5; RMA1; RING5; ring finger protein 5, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase RNF5; protein G16; ram1 homolog
Cat.#:RNF5-2347HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RNF5, GST-tagged
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Cat.#:RNF5-609HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RNF5
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Cat.#:RNF5-14352MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RNF5 Protein
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Cat.#:RNF5-5086RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RNF5 Protein
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Cat.#:RNF5-3946RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RNF5 Protein, His-tagged
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Cat.#:RNF5-549HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human RNF5 lysate
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Involved Pathway

Rnf5 involved in several pathways and played different roles in them. We selected most pathways Rnf5 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rnf5 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
SEC24B; ATXN3L; DNAJB1A; EDEM2; UBQLN3; MBTPS2; DAD1; HSP90AB1; CAPN2A; HSPA5

Protein Function

Rnf5 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity involved in ERAD pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by Rnf5 itself. We selected most functions Rnf5 had, and list some proteins which have the same functions with Rnf5. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein SIAH2L; TRIM69; HECW2; UBE2NA; TRIM9; PARK2; UBE2KA; MYLIPA; TRIM28; RNF133
Function protein binding
Related Protein DCTN5; COX17; STAG2; WNK1; HIST3H3; GMPPA; MCM8; PVRL3; EIF4H; ZFP161
Function ubiquitin protein ligase activity involved in ERAD pathway
Related Protein PARK2; TRIM25; RNF5; AMFR; SYVN1; STUB1; RNF185; TMEM129
Function ubiquitin-protein transferase activity
Related Protein TRIM17; UBE2D1; PEX2; UBE3C; UBE2S; RNF141; RNF5; ANKIB1; RNF151; RBBP6
Function zinc ion binding
Related Protein ABP1; TRIM32; S100A5; CYLD; SORD; ZNF3; RARGB; AFG3L2; LHX2A; NR2F1A

Interacting Protein

Rnf5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rnf5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rnf5.
UBE2D3; UBE2E3; UBE2D1; UBE2E2

Rnf5 Related Articles

Qin, Y; Zhou, MT; et al. RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms. PLOS PATHOGENS 10:-(2014).
Bernasconi, R; Galli, C; et al. Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway. MOLECULAR CELL 52:783-793(2013).