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SCIN

Official Full Name

scinderin
Overview

SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 (PubMed 11568009)).
Synonyms

SCIN; scinderin; adseverin; KIAA1905;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SCIN-2533H	Recombinant Human SCIN, GST-tagged	E.coli	GST	N-term-357aa	$319 / 25ug
Human	SCIN-1568HCL	Recombinant Human SCIN cell lysate		N/A		Inquiry
Human	SCIN-1445H	Recombinant Human SCIN Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	SCIN-14748M	Recombinant Mouse SCIN Protein	Mammalian Cell	His		Inquiry
Mouse	Scin-5714M	Recombinant Mouse Scin Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	SCIN-7933M	Recombinant Mouse SCIN Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SCIN-7933M-B	Recombinant Mouse SCIN Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SCIN-4160Z	Recombinant Zebrafish SCIN	Mammalian Cell	His		Inquiry
Chicken	SCIN-4517C	Recombinant Chicken SCIN	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SCIN Related Articles

SCIN involved in several pathways and played different roles in them. We selected most pathways SCIN participated on our site, such as Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fc gamma R-mediated phagocytosis	RPS6KB1;PRKCB;PIK3R1;RPS6KB2;PLA2G4D;PRKCG;BIN1;MYO10;NCF1
Regulation of actin cytoskeleton	RAF1B;ITGA11A;MYLPFB;CYFIP2;FGF5;MYLK4;INS2;SSH3;ROCK2B
Viral carcinogenesis	HIST1H2BC;TRAF2;HIST1H4N;ACTN4;PKM2;GTF2E2;HDAC1;HDAC11;PSMC1

SCIN has several biochemical functions, for example, 1-phosphatidylinositol binding, actin binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCIN itself. We selected most functions SCIN had, and list some proteins which have the same functions with SCIN. You can find most of the proteins on our site.

Function	Related Protein
1-phosphatidylinositol binding	SNX9;ZFYVE9;SNX10;WDFY3;PICALMA;FRMPD2;PICALM;SNAP91;PLEKHA4
actin binding	VPS18;TNNI1;WASH;NCALD;ACTR2A;LIMCH1A;EPB49;TBCCD1;FSCN2B
actin filament binding	MYH9;FLNA;TMEM201;AIF1L;ANTXR1;SLC6A4;MACF1;PPP1R9B;FSCN1
calcium ion binding	PLCZ1;C1S;RCVRNA;CAPN1B;SNCB;EGFL6;CAPNS1;NKD2B;MMP30
phosphatidylinositol-4,5-bisphosphate binding	COMMD1;FAM21C;PARD3;TWF1;ALOX15;VIL1;FRMPD4;KRIT1;ACTN2
phosphatidylserine binding	SYTL2;RASGRP1;PLCD1;MARK1;ANXA9;RS1;AXL;TRIM72;SDPR

SCIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCIN here. Most of them are supplied by our site. Hope this information will be useful for your research of SCIN.

MAP3K3; RIPK3; GRB2

Swierstra, J; Debets, S; et al. IgG4 Subclass-Specific Responses to Staphylococcus aureus Antigens Shed New Light on Host-Pathogen Interaction. INFECTION AND IMMUNITY 83:492-501(2015).

Garcia, BL; Ramyar, KX; et al. Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins. CURRENT TOPICS IN INNATE IMMUNITY II 946:113-133(2012).