scin
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  • Official Full Name
  • scinderin
  • Background
  • SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 (PubMed 11568009)).
  • Synonyms
  • SCIN; scinderin; adseverin; KIAA1905
Cat.#:SCIN-2533HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SCIN, GST-tagged
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Cat.#:SCIN-14748MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SCIN Protein
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Cat.#:SCIN-4517CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SCIN
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Cat.#:SCIN-4160ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SCIN
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Cat.#:SCIN-1568HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SCIN cell lysate
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Involved Pathway

SCIN involved in several pathways and played different roles in them. We selected most pathways SCIN participated on our site, such as Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCIN were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fc gamma R-mediated phagocytosis
WASL; RAC1; HCK; WAS; PRKCA; VAV2; FCGR3A; CFL2; PRKCE; PLD2
Regulation of actin cytoskeleton
HRASA; ARPC4L; MOS; CHRM5B; MYL2B; FGF21; ACTN1; PDGFA; PAK2A; PIP5K1C
Viral carcinogenesis
STAT3; GTF2E1; HIST1H2BM; CDC20; CDK1; HIST1H2BN; NRAS; GTF2B; HIST1H4D; HIST1H4F

Protein Function

SCIN has several biochemical functions, for example, 1-phosphatidylinositol binding, actin binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCIN itself. We selected most functions SCIN had, and list some proteins which have the same functions with SCIN. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol binding
Related Protein PLEKHA3; SCARB1; CCDC167; EPB41; PLEKHA2; ZFYVE1; PICALMA; SNX10; SCIN; EEA1
Function actin binding
Related Protein ABRA; SNTB1; EMD; SHROOM1; SMTNL; MSRB1A; HIP1; SPNA1; EPS8L2; DSTN
Function actin filament binding
Related Protein ACTN4; MYH11; TRPV4; AJUBA; AIF1L; HIST1H2AH; ACTN1; NEBL; BLOC1S6; ACTN2B
Function calcium ion binding
Related Protein PCDHGC3; ATP2A1; THBS3B; PPP2R3A; OCM; PCDH1G18; EPD; CAPN13; S100A6; FBN1
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein KCNQ1; SCIN; CHMP3; Apba1; RAG2; FAM123B; ADAP2; TWF1; PARD3; ACTN2
Function phosphatidylserine binding
Related Protein OSBPL5; THBS1; CD300A; TRIM72; RPE65; AXL; RS1; SYT4; CPNE6; RASGRP1

Interacting Protein

SCIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCIN here. Most of them are supplied by our site. Hope this information will be useful for your research of SCIN.
MAP3K3; RIPK3; GRB2

SCIN Related Articles

Swierstra, J; Debets, S; et al. IgG4 Subclass-Specific Responses to Staphylococcus aureus Antigens Shed New Light on Host-Pathogen Interaction. INFECTION AND IMMUNITY 83:492-501(2015).
Garcia, BL; Ramyar, KX; et al. Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins. CURRENT TOPICS IN INNATE IMMUNITY II 946:113-133(2012).