sec61a1
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  • Official Full Name
  • Sec61 alpha 1 subunit (S. cerevisiae)
  • Background
  • The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits.
  • Synonyms
  • SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae); protein transport protein Sec61 subunit alpha isoform 1; chunp6898; fb62c11; HSEC61; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; SEC 61; SEC 61A; Sec61 alpha 1; Sec61 alpha 1 subunit; SEC61; Sec61 homolog; sec61aa; Sec61 alpha-1; SEC61A
Cat.#:SEC61A1-14838MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SEC61A1 Protein
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Cat.#:SEC61A1-5303RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SEC61A1 Protein
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Cat.#:SEC61A1-4126RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SEC61A1 Protein, His-tagged
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Cat.#:SEC61A1-9466ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SEC61A1
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Involved Pathway

SEC61A1 involved in several pathways and played different roles in them. We selected most pathways SEC61A1 participated on our site, such as Protein export, Protein processing in endoplasmic reticulum, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC61A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein export
SEC62; IMMP1L; SRP68; OXA1L; SPCS3; SPCS1; SRP54B; SRPR; SEC11C; secB
Protein processing in endoplasmic reticulum
VIMP; UBQLN1; BCAP31; WFS1; NPLOC4; HSPA1B; UBQLN3; PDIA3; RAD23AB; DNAJC5G
Phagosome
HLA-DOB; TUBB1; TUBA3C; ATP6V0C; THBS4A; STX18; MRC2; TUBAL3; SEC61G; CTSSA

Protein Function

SEC61A1 has several biochemical functions, for example, ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC61A1 itself. We selected most functions SEC61A1 had, and list some proteins which have the same functions with SEC61A1. You can find most of the proteins on our site.
Function
Related Protein
Function ribosome binding
Related Protein EIF5A; MTRF1; ABCF1; EFTUD1; CPEB4; MTRF1L; EIF3K; EIF5A2; ETF1; ICT1

Interacting Protein

SEC61A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC61A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC61A1.
Tmem173

SEC61A1 Related Articles

Wheeler, MC; Gekakis, N; et al. Hsp90 modulates PPAR gamma activity in a mouse model of nonalcoholic fatty liver disease. JOURNAL OF LIPID RESEARCH 55:1702-1710(2014).
Lang, S; Benedix, J; et al. Different effects of Sec61 alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. JOURNAL OF CELL SCIENCE 125:1958-1969(2012).