senp5
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  • Official Full Name
  • SUMO1/sentrin specific peptidase 5
  • Background
  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see;SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are;responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the;conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO;conjugates (Di Bacco et al., 2006 (PubMed 16738315)).
  • Synonyms
  • SENP5; SUMO1/sentrin specific peptidase 5; SUMO1/sentrin specific protease 5; sentrin-specific protease 5; MGC27076; sentrin/SUMO-specific protease SENP5; FLJ42398; DKFZp564O1016
Cat.#:SENP5-14881MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SENP5 Protein
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Cat.#:SENP5-908CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus SENP5 Protein, His-tagged
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Cat.#:SENP5-4139RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SENP5 Protein, His-tagged
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Cat.#:SENP5-5053ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SENP5
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Cat.#:SENP5-1973HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SENP5 293 Cell Lysate
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Involved Pathway

SENP5 involved in several pathways and played different roles in them. We selected most pathways SENP5 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism of proteins
PFDN4; MUC12; FKBP14; IGFBP2B; TRAPPC6BL; EXOC5; CCT7; CEACAM21; ADAMTS3; UBA2
Post-translational protein modification
TRAPPC6BL; ADAMTS5; MLEC; MUC12; NAPAB; MUCL1; MAN1B1; ADAMTS8; MUC1; CNIH
Processing and activation of SUMO
SAE1; SENP1; UBA2; SENP5
SUMO is proteolytically processed
SENP1; SENP5
SUMOylation
NSMCE2; SENP1; EID3; SENP5; PHC1; NSMCE4A; SMC5; CBX8; NSMCE1; SAE1

Protein Function

SENP5 has several biochemical functions, for example, SUMO-specific protease activity, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP5 itself. We selected most functions SENP5 had, and list some proteins which have the same functions with SENP5. You can find most of the proteins on our site.
Function
Related Protein
Function SUMO-specific protease activity
Related Protein SENP3B; SENP3; SENP3A; SENP6; SENP1; SENP5
Function endopeptidase activity
Related Protein AP1S2; SENP5; NAPSA; Ren1; KLK1B26; RHBDD1; ACE; PSMB4; SENP3; F9
Function protein binding
Related Protein COPB1; UFL1; SERP1; VWF; LILRB3; PHF7; CCDC28A; GATA2; C7orf25; NRG1

Interacting Protein

SENP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP5.
ESR1

SENP5 Related Articles

Kim, EY; Zhang, Y; et al. SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 78:154-164(2015).
Wang, K; Zhang, XC; et al. Inhibition of SENP5 suppresses cell growth and promotes apoptosis in osteosarcoma cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 7:1691-1695(2014).