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SEPT5

Official Full Name

septin 5
Overview

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Synonyms

SEPT5; septin 5; peanut like 1 (Drosophila) ; PNUTL1; septin-5; H5; HCDCREL 1; 5 Sep; CDCrel 1; CDCREL; CDCrel-1; CDCREL1; Cell division control related protein 1; Cell division control-related protein 1; H5; HCDCREL 1; OTTHUMP00000197271; OTTHUMP00000197272; OTTHUMP00000197273; OTTHUMP00000197274; OTTHUMP00000197275; OTTHUMP00000197276; OTTHUMP00000197396; OTTHUMP00000197410; Peanut like 1; Peanut like 1 homolog; Peanut like protein 1; Peanut-like protein 1; Platelet glycoprotein Ib beta chain; PNUTL1; SEPT5; SEPT5_HUMAN; Septin 5; Septin-5; peanut-like 1; platelet glycoprotein Ib beta chain; cell division control related protein 1; CDCREL; PNUTL1; CDCREL1; CDCREL-1; HCDCREL-1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST|His
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SEPT5-3591H	Recombinant Human SEPT5, His-tagged	E.coli	His		Inquiry
Human	SEPT5-30597TH	Recombinant Human SEPT5, HIS-tagged	E.coli	His	369 amino acids	Inquiry
Human	SEPT5-31398TH	Recombinant Human SEPT5, HIS-tagged	E.coli	His		Inquiry
Human	SEPT5-30599TH	Recombinant Human SEPT5, HIS-tagged	E.coli	His	369 amino acids	Inquiry
Human	SEPT5-5249H	Recombinant Human SEPT5 Protein, GST/His-tagged	E.coli	GST/His		Inquiry
Human	SEPT5-1957HCL	Recombinant Human SEPT5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SEPT5-356H	Recombinant Human SEPT5 Protein, His-tagged	E.coli	His	Ser77~Ser323	$298 / 10ug
Mouse	SEPT5-14895M	Recombinant Mouse SEPT5 Protein	Mammalian Cell	His		Inquiry
Mouse	SEPT5-8027M-B	Recombinant Mouse SEPT5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SEPT5-8027M	Recombinant Mouse SEPT5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SEPT5-5327R	Recombinant Rat SEPT5 Protein	Mammalian Cell	His		Inquiry
Rat	SEPT5-4986R	Recombinant Rat SEPT5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SEPT5-4986R-B	Recombinant Rat SEPT5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	SEPT5-2360C	Recombinant Chicken SEPT5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SEPT5 Related Articles

SEPT5 involved in several pathways and played different roles in them. We selected most pathways SEPT5 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEPT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Parkinsons disease	NDUFA10;SLC25A5;COX7A2L;CYCS;PRKACA;NDUFC1;PRKACG;NDUFS5;ATP5A1

SEPT5 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEPT5 itself. We selected most functions SEPT5 had, and list some proteins which have the same functions with SEPT5. You can find most of the proteins on our site.

Function	Related Protein
GTP binding	RHOB;GNAI2B;RASL12;GSPT1L;RND3;TUBA3E;GMPPAA;GNL3L;NKIRAS2
GTPase activity	GNA14;RAB7A;DNM1A;RABL5;RAB36;MX2;DNM2A;RAB27B;TUBAL3
protein binding	CCDC9;MGST3;NEU4;DPP4;MAP3K11;RAVER2;SGTA;DAZAP2;SEPT12
structural molecule activity	JUP;KRTT1C19E;KRT97;LAD1;Sprr2i;CLDN5B;KRT222;TUBA1A;PSMD13

SEPT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEPT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEPT5.

SEPT11; SEPT10; SEPT6; SEPT2; SEPT1

Zeraik, AE; Rinaldi, G; et al. Septins of Platyhelminths: Identification, Phylogeny, Expression and Localization among Developmental Stages of Schistosoma mansoni. PLOS NEGLECTED TROPICAL DISEASES 7:-(2013).

Tsang, CW; Estey, MP; et al. Characterization of presynaptic septin complexes in mammalian hippocampal neurons. BIOLOGICAL CHEMISTRY 392:739-749(2011).