serpina3
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  • Official Full Name
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
  • Background
  • The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
  • Synonyms
  • SERPINA3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; ACT; AACT; GIG24; GIG25; alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3
Cat.#:a1ACT-3300HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human a1ACT, His-tagged, GST-tagged
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Cat.#:SERPINA3-665HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINA3, His tagged
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Cat.#:SERPINA3-257HTag:His
Source (Host):Mammalian CellsSpecies:Horse
Product nameRecombinant Horse SERPINA3 protein, His-tagged
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Cat.#:SERPINA3-487HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINA3
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Cat.#:SERPINA3-27285THTag:
Source (Host):Species:Human
Product nameNative Human SERPINA3
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Cat.#:SERPINA3-5331HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin), Member 3
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Cat.#:SERPINA3-8008HTag:N/A
Source (Host):Human SerumSpecies:Human
Product nameNative Human Serum Alpha 1-AntiChymoTrypsin
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Cat.#:SERPINA3-8349HTag:
Source (Host):Pooled normal human serum.Species:Human
Product nameNative Human SERPINA3
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Cat.#:SERPINA3-2522HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINA3 cell lysate
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Involved Pathway

SERPINA3 involved in several pathways and played different roles in them. We selected most pathways SERPINA3 participated on our site, such as Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Selenium Pathway
DIO2; ALOX5AP; PRDX2; SELK; PRDX3; SERPINA3; TXNRD3IT1; SAA4; CRP; SAA2-SAA4

Protein Function

SERPINA3 has several biochemical functions, for example, DNA binding, protein binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINA3 itself. We selected most functions SERPINA3 had, and list some proteins which have the same functions with SERPINA3. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein SNAPC4; ZNF777; TBX2A; ARID4A; VENT; ENO1; SOX1B; FOXG1D; THRB; ZNF597
Function protein binding
Related Protein RABL2A; FANCC; FAM114A1; PPP1CC; SERPINA3; MIA3; RIPPLY1; MLLT10; CXorf48; TFRC
Function serine-type endopeptidase inhibitor activity
Related Protein PAPLNB; SERPINI1; EPPIN; PAPLN; WFDC6B; AGT; WFDC12; SERPINB4; SERPINB13; HRG

Interacting Protein

SERPINA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINA3.
DNAJC1; KLK3; ABCC5; ADH1B; NFKB1; LMNB1; SGCD; ZNRD1; LAMC3; ATP6V1A

SERPINA3 Related Articles

Jennings, P; Crean, D; et al. Interleukin-19 as a translational indicator of renal injury. ARCHIVES OF TOXICOLOGY 89:101-106(2015).
Amico, AD; Ragusa, R; et al. Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).