SETD8 Protein, SET domain containing (lysine methyltransferase) 8

SETD8

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SETD8

Official Full Name SET domain containing (lysine methyltransferase) 8
Background SET domain-containing lysine methyltransferase 8 (SET8), also known as PR/SET domain-containing protein 7 (PR/SET7), is a member of a family of histone lysine methyltransferases, each of which contains a conserved catalytic SET domain originally identifie
Synonyms SETD8; SET domain containing (lysine methyltransferase) 8; N-lysine methyltransferase SETD8; KMT5A; PR Set7; SET07; SET8; PR/SET07; H4-K20-HMTase SETD8; lysine N-methyltransferase 5A; SET domain-containing protein 8; PR/SET domain containing protein 8; PR
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SETD8-1631H Recombinant Human SET Domain Containing (lysine methyltransferase) 8, GST-tagged Sf9 Insect Cell GST
    Human SETD8-187H Recombinant Human SETD8 Protein, His-tagged E.coli His
    Human SETD8-1924HCL Recombinant Human SETD8 293 Cell Lysate HEK293 N/A
    Human SETD8-2608H Recombinant Human SETD8, His-tagged E.coli His
    Human SETD8-461H Recombinant Human SETD8, GST-tagged E.coli GST
    Human SETD8-6964H Recombinant Human SETD8, GST-tagged Sf9 Insect Cell GST
    Human SETD8-886H Recombinant Human SETD8, None tagged E.coli N/A

    SETD8 involved in several pathways and played different roles in them. We selected most pathways SETD8 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lysine degradation HADHAB; SETDB1B; KMT2E; TMLHE; ALDH3A2A; MLL1; SETDB2; EHMT2; CAMKMT; ALDH2.1

    SETD8 has several biochemical functions, for example, histone-lysine N-methyltransferase activity, p53 binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETD8 itself. We selected most functions SETD8 had, and list some proteins which have the same functions with SETD8. You can find most of the proteins on our site.

    Function Related Protein
    histone-lysine N-methyltransferase activity SUV39H1; EHMT1B; PRDM6; PRDM9; WBP7; SETD2; EHMT2; MLL5; WHSC1L1; SMYD2A
    p53 binding SMARCA4; AXIN1; ZFP385C; NTRK3; ZNF385A; HSPD1; STK11; SETD7; TRIAP1; TRP63
    protein binding MRPL49; VIPAS39; DMC1; CAML; ARHGEF16; ATP6V1E2; IL17F; RAD9; MZF1; TLX2
    protein-lysine N-methyltransferase activity EHMT1; EHMT2; SMYD2; FAM119A; FAM86A; METTL20; METTL23; RNMTL1B; TRMT10B; METTL21D
    transcription corepressor activity SUFU; ZFPM2; HIPK2; LHX1; DR1; ASXL1; NFIL3; SKIL; C1QBP; TRIB3

    SETD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETD8.

    HIST2H4B; TWIST1; FAM9A

    Rabello, DD; De Moura, CA; et al. Altered expression of MLL methyltransferase family genes in breast cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 43:653-660(2013).
    Yu, N; Huangyang, PW; et al. microRNA-7 Suppresses the Invasive Potential of Breast Cancer Cells and Sensitizes Cells to DNA Damages by Targeting Histone Methyltransferase SET8. JOURNAL OF BIOLOGICAL CHEMISTRY 288:19633-19642(2013).

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