• Official Full Name
  • senataxin
  • Background
  • This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).
  • Synonyms
  • SETX; senataxin; ALS4, amyotrophic lateral sclerosis 4 , SCAR1, spinocerebellar ataxia, recessive, non Friedreich type 1; probable helicase senataxin; AOA2; KIAA0625; ALS4; Amyotrophic lateral sclerosis 4 protein; bA479K20.2; DKFZp781B151; FLJ12840; FLJ43459; SCAR1; SEN1 homolog; SETX_HUMAN; OTTHUMP00000022428
Source (Host):HEK293Species:Human
Product nameRecombinant Human SETX Protein, MYC/DDK-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SETX Protein

Protein Function

SETX has several biochemical functions, for example, ATP binding, helicase activity, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SETX itself. We selected most functions SETX had, and list some proteins which have the same functions with SETX. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein STK32C; EPHB2; ADCY3; TTBK1; ABCB6A; GM711; ITPKC; DHX30; UCK2A; RFC5
Function helicase activity
Related Protein DDX58; CHD6; MCM6L; DHX32A; EIF4A1; SHPRH; SNRNP200; DICER1; TDRD9; HELZ
Function hydrolase activity
Related Protein ABHD16B; ATP8B5; NUDT21; ATP8B3; ATP1A3A; OTUB1A; PGCP; ATP6V0E; ATP2B2; HDHD3
Function identical protein binding
Related Protein HSPB8; Serpina1c; KHDRBS1; PYCARD; DAAM1; IFI16; CLDN16; WRNIP1; ZNF212; CPT1A
Function nucleotide binding
Function protein binding
Related Protein KIF14; NR1H4; GNG4; NOC4L; ZNF202; MLLT6; C12orf43; CAV1; AXIN1; RUVBL2
Function transcription termination site sequence-specific DNA binding
Related Protein SETX; XRN2

Interacting Protein

SETX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETX here. Most of them are supplied by our site. Hope this information will be useful for your research of SETX.
Ezh2; Jarid2; Eed