sf3b2
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  • Official Full Name
  • splicing factor 3b, subunit 2, 145kDa
  • Background
  • This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.
  • Synonyms
  • SF3B2; splicing factor 3b, subunit 2, 145kDa; splicing factor 3b, subunit 2, 145kD; splicing factor 3B subunit 2; Cus1; SAP145; SF3b1; SF3b145; SAP 145; spliceosome associated protein 145; spliceosome-associated protein 145; pre-mRNA splicing factor SF3b
Cat.#:SF3B2-6004ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SF3B2
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Cat.#:SF3B2-1917HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SF3B2 293 Cell Lysate
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Involved Pathway

SF3B2 involved in several pathways and played different roles in them. We selected most pathways SF3B2 participated on our site, such as Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3B2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
CRCP; C2orf29; DNMT1; ZNF718; MBD3A; CPSF4; HNRNPA2B1; NR2E3; WTAP; NR0B2A
Processing of Capped Intron-Containing Pre-mRNA
HNRNPA0B; TTC6; HNRPL; ZCRB1; HNRNPA0L; DNAJC8; HNRNPL; CCAR1; RNPS1; HNRNPF
Spliceosome
SRSF1A; SRSF2A; MAGOH2; ISY1-RAB43; SRSF5; SF3A2; PUF60; PRPF18; PRPF6; TRA2B
mRNA Splicing
PCBP2; SF3B4; HNRNPD; PRPF8; HNRNPA0A; PDCD7; HNRPL; PTBP1; HNRNPA0; SF3A3
mRNA Splicing - Major Pathway
SF3A1; HNRNPH1L; HNRNPA0B; HNRNPA2B1; HNRNPA0; RBM5; PCBP2; SF3B2; HNRNPA0L; BCAS2
mRNA Splicing - Minor Pathway
PRPF8; SF3B4; SNRNP35; YBX1; SF3B2; RNPC3; ZMAT5; TXNL4A; ZCRB1; SNRNP48
mRNA processing
HNRNPH1; EIF4E3; PPM1G; CLASRP; SFRS3A; ZFP622; PTBP2; PRPF4BB; NONO; Ankar

Protein Function

SF3B2 has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3B2 itself. We selected most functions SF3B2 had, and list some proteins which have the same functions with SF3B2. You can find most of the proteins on our site.
Function
Related Protein
Function poly(A) RNA binding
Related Protein REPIN1; CSTF2; NONO; ZC3H8; CSTF2T; PARP1; UBE2O; SRPK2; ETF1; EXOSC10
Function protein binding
Related Protein FAM46A; ATN1; STXBP2; APPBP2; DDX21; SYT11; RGS3; CENPW; MAU2; GPR19

Interacting Protein

SF3B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3B2.
SF3B4; RNF113A; PRPF3; DHX16; KDM1A; SLU7; U2AF1; PRPF8; FRA10AC1

SF3B2 Related Articles

Xu, WJ; Huang, HX; et al. Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC). MEDICAL ONCOLOGY 32:-(2015).
Zhu, J; Chen, WR; et al. Ethoxyquin Prevents Chemotherapy-Induced Neurotoxicity via Hsp90 Modulation. ANNALS OF NEUROLOGY 74:893-904(2013).