sgpp1
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  • Official Full Name
  • sphingosine-1-phosphate phosphatase 1
  • Background
  • Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1;catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al.,;2000 (PubMed 10859351); Le Stunff et al., 2007 (PubMed 17895250)).
  • Synonyms
  • SGPP1; sphingosine-1-phosphate phosphatase 1; hSPPase1; Sphingosine-1-phosphatase 1; Spp1; SPPase1; hSPP1
Cat.#:SGPP1-2633HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SGPP1, GST-tagged
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Involved Pathway

SGPP1 involved in several pathways and played different roles in them. We selected most pathways SGPP1 participated on our site, such as Sphingolipid metabolism, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGPP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid metabolism
ARSJ; SPHK1; UGT8; VAPB; ASAH2; PPAP2CB; LASS5; SGPL1; NEU3.1; PPAP2C
Sphingolipid signaling pathway
PIK3CB; TRAF2; NOS3; NFKB1; PPP2R2C; PPP2R1A; SGMS2; OPRD1; PIK3R5; ASAH1

Protein Function

SGPP1 has several biochemical functions, for example, sphingosine-1-phosphate phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SGPP1 itself. We selected most functions SGPP1 had, and list some proteins which have the same functions with SGPP1. You can find most of the proteins on our site.
Function
Related Protein
Function sphingosine-1-phosphate phosphatase activity
Related Protein SGPP1; SGPP2; PPAP2B

Interacting Protein

SGPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGPP1.
TUBG1; TMEM63B; GOLT1B

SGPP1 Related Articles

You, S; Piali, L; et al. Therapeutic Use of a Selective S1P(1) Receptor Modulator Ponesimod in Autoimmune Diabetes. PLOS ONE 8:-(2013).
Carr, JM; Mahalingam, S; et al. Sphingosine kinase 1 in viral infections. REVIEWS IN MEDICAL VIROLOGY 23:73-84(2013).