SH3GL1

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SH3GL1

Official Full Name SH3-domain GRB2-like 1
Background This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms SH3GL1; SH3-domain GRB2-like 1; endophilin-A2; CNSA1; EEN; extra 11 19 leukemia fusion; fusion partner of MLL; MGC111371; SH3 domain GRB2 like 1; SH3 containing Grb 2 like 1 protein; SH3 containing protein EEN; SH3D2B; SH3P8; EEN fusion partner of MLL; Endophilin-2; Extra 11 19 leukemia fusion gene; Extra eleven-nineteen leukemia fusion gene protein; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3G1_HUMAN; extra 11-19 leukemia fusion; SH3-containing Grb-2-like 1 protein
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SH3GL1-2104H Recombinant Human SH3GL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Sh3gl1-5844M Recombinant Mouse Sh3gl1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human SH3GL1-1868HCL Recombinant Human SH3GL1 293 Cell Lysate HEK293 N/A
    Human SH3GL1-300H Recombinant Human SH3GL1 protein, MYC/DDK tagged HEK293 Myc/DDK
    Human SH3GL1-301H Recombinant Human SH3GL1 protein, GST tagged Wheat Germ GST
    Human SH3GL1-30812TH Recombinant Human SH3GL1, His-tagged E.coli His
    Rat SH3GL1-5378R Recombinant Rat SH3GL1 Protein Mammalian Cell His
    Chicken SH3GL1-6098C Recombinant Chicken SH3GL1 Mammalian Cell His

    SH3GL1 involved in several pathways and played different roles in them. We selected most pathways SH3GL1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH3GL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis FGFR3; RAB4A; FOLR2; EHD1B; WIPF1; FOLR3; GRK6; SH3GL2; IL2RGB; SMAD3A

    SH3GL1 has several biochemical functions, for example, GTPase binding, identical protein binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH3GL1 itself. We selected most functions SH3GL1 had, and list some proteins which have the same functions with SH3GL1. You can find most of the proteins on our site.

    Function Related Protein
    GTPase binding STOML2; MARCH5; GM5506; GNB3; IARS; RAB3D; YBX1; PTPRN; GNB2; EPRS
    identical protein binding GLUL; TRIM5; PDCD6; MVK; DNMT3A; SNX16; DNM1; CRYBB2; CCL3; EDC3
    lipid binding SH3GL1; FABP10A; FAM123B; PFN4; APOA2; ACBD5A; BPIFB6; DBI; AP2A2; ATP5G3
    phosphatase binding SLC9A3R1; CTSC; MAGI2; PPP1R35; SMAD2; CRY2; SH2D4A; SMAD3; SLC9A3R2; DYSFIP1
    protein binding TLDC2; FOXP4; PEF1; HSP90AA1; ZBTB26; ZMYND19; TLX2; CLTB; GNA14; RELA

    SH3GL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH3GL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH3GL1.

    DPPA4; SH3GL3; BPGAP1; SH2D4A

    Matsutani, T; Hiwasa, T; et al. Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 31:-(2012).
    Matsutani, T; Iwadate, Y; et al. AUTOLOGOUS SH3-DOMAIN GRB2-LIKE 1 (SH3GL1) ANTIBODY AS A NOVEL SERUM MARKER SPECIFIC TO LOW-GRADE GLIOMA. NEURO-ONCOLOGY 11:898-898(2009).

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