shox
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  • Official Full Name
  • short stature homeobox
  • Background
  • This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Synonyms
  • SHOX; short stature homeobox; short stature homeobox protein; GCFX; PHOG; SHOXY; SS; Growth control factor, X linked; Homo sapiens shox gene, alternatively spliced products, complete cds; Pseudoautosomal homeobox containing osteogenic; Pseudoautosomal homeobox containing osteogenic protein; Short stature homeobox containing protein; Turner syndrome; growth control factor, X-linked; short stature homeobox-containing protein; pseudoautosomal homeobox-containing osteogenic protein
Cat.#:SHOX-2664HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SHOX, GST-tagged
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Cat.#:SHOX-3557CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SHOX
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Cat.#:SHOX-6725ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SHOX
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Cat.#:SHOX-1603HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SHOX cell lysate
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Protein Function

SHOX has several biochemical functions, for example, protein binding, sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHOX itself. We selected most functions SHOX had, and list some proteins which have the same functions with SHOX. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein WNT3; AVPR1A; KIF9; ANK1; LPL; TAOK1; BAZ2B; TMEM185A; ITGB5; ACTG1
Function sequence-specific DNA binding
Related Protein NKX2.4B; ATF4B1; ZKSCAN4; NKX6.2; HOXB7A; ATF7A; HOXC6; ASCL1A; ZBTB33; IRX1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein SMAD5; ZNF583; GPBP1; HMGA1B; FOXL2; GABPB1; DBPA; TCEAL1; CREBL2; NCOR1

Interacting Protein

SHOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHOX here. Most of them are supplied by our site. Hope this information will be useful for your research of SHOX.
SOX5; SOX6; Sox5; Sox6

SHOX Related Articles

Binder, G; Ranke, MB; et al. Auxology is a valuable instrument for the clinical diagnosis of SHOX haploinsufficiency in school-age children with unexplained short stature. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 88:4891-4896(2003).