shpk
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  • Official Full Name
  • sedoheptulokinase
  • Background
  • The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements.
  • Synonyms
  • SHPK; sedoheptulokinase; carbohydrate kinase like , CARKL; SHK; Carbohydrate kinase like; Carbohydrate kinase like protein; Carbohydrate kinase-like protein; CARKL; SHPK_HUMAN; OTTHUMP00000115862
Cat.#:SHPK-1329HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human SHPK Protein, GST-Tagged
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Cat.#:SHPK-244HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SHPK, His-GST tagged
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Cat.#:SHPK-265HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SHPK, Gly&Pro tagged
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Cat.#:SHPK-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SHPK cell lysate
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Cat.#:SHPK-002HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SHPK cell lysate
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Protein Function

SHPK has several biochemical functions, for example, ATP binding, sedoheptulokinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SHPK itself. We selected most functions SHPK had, and list some proteins which have the same functions with SHPK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CAMKV; RPS6KA3A; HELB; P2RY4; DNAJA2L; AK7; HSPA4; STK32A; KALRN; DDX5
Function sedoheptulokinase activity
Related Protein SHPK

Interacting Protein

SHPK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHPK here. Most of them are supplied by our site. Hope this information will be useful for your research of SHPK.
MDM2

SHPK Related Articles

Wamelink, MMC; Struys, EA; et al. Elevated concentrations of sedoheptulose in bloodspots of patients with cystinosis caused by the 57-kb deletion: Implications for diagnostics and neonatal screening. MOLECULAR GENETICS AND METABOLISM 102:339-342(2011).
Wamelink, MMC; Struys, EA; et al. Sedoheptulokinase deficiency due to a 57-KB deletion in cystinosis patients causes accumulation of sedoheptulose: elucidation of the function of the carkl gene. PEDIATRIC NEPHROLOGY 24:905-905(2009).