• Official Full Name
  • single-minded homolog 2 (Drosophila)
  • Background
  • SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription;factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal;region. Based on the mapping position, its potential function as transcriptional repressor and similarity to;Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes.
  • Synonyms
  • SIM2; single-minded homolog 2 (Drosophila); SIM, single minded (Drosophila) homolog 2; single-minded homolog 2; bHLHe15; MGC119447; transcription factor SIM2; Class E basic helix loop helix protein 15; Class E basic helix-loop-helix protein 15; SIM 2; SIM; SIM2_HUMAN; Single minded homolog 2 (Drosophila); Single minded homolog 2; OTTHUMP00000109043; OTTHUMP00000109044; single-minded homolog 2, short isoform; HMC13F06; HMC29C01
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIM2, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SIM2 Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SIM2

Protein Function

SIM2 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIM2 itself. We selected most functions SIM2 had, and list some proteins which have the same functions with SIM2. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein FOXJ1; FOXN1; ATF4B1; FOXC1B; PAX6A; SP2; RELB; POU5F1; ZNF131; RUNX2B
Function protein heterodimerization activity
Related Protein ATF2; RARA; TAS1R1; HNF1B; NFE2L2A; CA; STX1A; SOX6; TBX18; INHA
Function transcription factor activity, sequence-specific DNA binding
Related Protein SRF; SS18L1; ZNF354A; MESPBA; FOXP3; ZNF26; SALL1; CEBPD; ZFP161; NR1H5

Interacting Protein

SIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIM2.
Dlg4; a8k1f4_human; b4dyc6_human; AIP; SGTA; BAG4; BAG2; HSPB1; HSP90AB1; STIP1; MLF1; PSMD2; FKBP5; PTGES3; HSP90AB1; NUDCD3; Hacd3; q96be0_human; TTC1; PPP5C

SIM2 Related Articles

Spellman, C; Ahmed, MM; et al. Expression of trisomic proteins in Down syndrome model systems. GENE 512:219-225(2013).
Arredouani, MS; Lu, B; et al. Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer. CLINICAL CANCER RESEARCH 15:5794-5802(2009).