sirt4
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  • Official Full Name
  • sirtuin 4
  • Background
  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
  • Synonyms
  • SIRT4; sirtuin 4; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; NAD-dependent ADP-ribosyltransferase sirtuin-4; SIR2L4; sir2-like 4; sirt
Cat.#:SIRT4-2682HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT4, His-tagged
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Cat.#:SIRT4-30844THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT4
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Cat.#:SIRT4-30846THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT4
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Cat.#:SIRT4-465HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT4, GST-tagged
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Cat.#:SIRT4-4879HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sirtuin 4, GST-tagged
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Cat.#:Sirt4-1377MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sirt4 protein, His-tagged
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Cat.#:SIRT4-15154MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SIRT4 Protein
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Cat.#:Sirt4-1378RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sirt4 protein, His-tagged
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Cat.#:SIRT4-1513ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SIRT4
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Cat.#:SIRT4-1831HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SIRT4 293 Cell Lysate
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Involved Pathway

SIRT4 involved in several pathways and played different roles in them. We selected most pathways SIRT4 participated on our site, such as Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling events mediated by HDAC Class I
WDR77; GATA1; FKBP3; SIRT4; SIRT2; TFCP2; SIRT7; NR2C1; SIRT5; GATA2

Protein Function

SIRT4 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, NAD+ binding, NOT NAD-dependent protein deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT4 itself. We selected most functions SIRT4 had, and list some proteins which have the same functions with SIRT4. You can find most of the proteins on our site.
Function
Related Protein
Function NAD+ ADP-ribosyltransferase activity
Related Protein GIG2F; GIG2Q; ZC3HAV1; ART1; GIG2D; PARP11; PARP12; GIG2P; TNKS2; PARP2
Function NAD+ binding
Related Protein SIRT4; HPGD; SIRT1; SIRT6; GLUD1; UXS1; HADH; SIRT3; ALDH1A3; SIRT2
Function NOT NAD-dependent protein deacetylase activity
Related Protein SIRT4
Function biotinidase activity
Related Protein SIRT4; BTD
Function lipoamidase activity
Related Protein SIRT4
Function metal ion binding
Related Protein ZNF559-ZNF177; ZBTB26; GDPD2; E4F1; RPS27A; DPYD; NUDT13; TRIM27; BRD1B; CHORDC1B
Function protein binding
Related Protein NOL3; CCBL1; PPP6R3; THRA; GPR77; PAF1; TFCP2; NRAP; HIST1H2AM; UQCRH

Interacting Protein

SIRT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT4.
IDE; DLAT; PDHX; SLC25A5; SLC25A6; SKP2; VWA8; NDUFS2; PMPCB