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SIX4

Official Full Name

SIX homeobox 4
Overview

This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.
Synonyms

SIX4; SIX homeobox 4; sine oculis homeobox (Drosophila) homolog 4 , sine oculis homeobox homolog 4 (Drosophila); homeobox protein SIX4; AREC3; sine oculis homeobox homolog 4; MGC119450; MGC119452; MGC119453;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SIX4-1861H	Recombinant Human SIX4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	SIX4-15164M	Recombinant Mouse SIX4 Protein	Mammalian Cell	His	Inquiry
Mouse	SIX4-8188M	Recombinant Mouse SIX4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	SIX4-8188M-B	Recombinant Mouse SIX4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein

SIX4 involved in several pathways and played different roles in them. We selected most pathways SIX4 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	SPINT1;DOT1L;BCL6;PAX8;PBX3;RXRA;MMP9;MAF;LDB1

SIX4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIX4 itself. We selected most functions SIX4 had, and list some proteins which have the same functions with SIX4. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ABL1;DMBX1B;HER8.2;AHRR;ATOH7;ZNF134;PRDM13;TBR1B;CRSP7
RNA polymerase II core promoter proximal region sequence-specific DNA binding	BSX;HOXA7;PHOX2B;ZNF148;HOXD13;ZGPAT;GATA1;BATF2;MYC
protein binding	LAMTOR2;TRAM1;ACTR3;APOOL;ACTR8;AGBL1;MPZL3;DRAP1;UBE2D3
sequence-specific DNA binding	POUV;FOXO3A;ZFP42;SPI1A;HOXD4A;NKX2.4A;GATAD2AB;ISL1L;DHARMA
transcription factor activity, sequence-specific DNA binding	NFYAL;CDX2;BLZF1;NPAS1;GTF2I;ZNF812;GABPA;ZFP354A;MYT1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	SP1;WT1;GLIS2;MYOCD;MYBL1;TCF4;ISL1;TFAP2E;CAMTA2

SIX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIX4.

Kdm6a; Eya2