• Official Full Name
  • SIX homeobox 4
  • Background
  • This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.
  • Synonyms
  • SIX4; SIX homeobox 4; sine oculis homeobox (Drosophila) homolog 4 , sine oculis homeobox homolog 4 (Drosophila); homeobox protein SIX4; AREC3; sine oculis homeobox homolog 4; MGC119450; MGC119452; MGC119453
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SIX4 Protein

Involved Pathway

SIX4 involved in several pathways and played different roles in them. We selected most pathways SIX4 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIX4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Transcriptional misregulation in cancer
BCL2A1A; SFPI1; BMI1; CCNA1; TP53; DOT1L; ETV5; Pdgfa&Pdgfb; SSX1; BCL2A1

Protein Function

SIX4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIX4 itself. We selected most functions SIX4 had, and list some proteins which have the same functions with SIX4. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein GRHL1; ATF7; TBX20; GLI3; MEOX1; CRX; IFI203; HNRNPK; NFATC2; SMAD4
Function protein binding
Related Protein KIF5B; NDUFA13; AES; UPP2; OFCC1; CLDN16; ISCU; UBE2D4; SIX4; C9orf116
Function sequence-specific DNA binding
Related Protein ARGFX; NKX6.2; MIXL1; ZFP423; HLF; HOXD9A; IRX2A; ZC3H8; RX1; GLI1
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXD4; HLF; POU5F2; ELK3; SCML1; ZFP184; ZNF397; FOXF2A; MAFG; BRD8
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein FOXJ1; MYOG; E2F4; FOSB; ELK1; MZF1; MESP1; ISL1; PLAG1; WT1

Interacting Protein

SIX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIX4.
Kdm6a; Eya2