slc18a1
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  • Official Full Name
  • solute carrier family 18 (vesicular monoamine), member 1
  • Background
  • The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient;maintained across the vesicular membrane. Its proper function is essential to the correct activity of the;monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site;of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 (PubMed 7905859)). See also;SLC18A2 (MIM 193001).
  • Synonyms
  • SLC18A1; solute carrier family 18 (vesicular monoamine), member 1; VAT1, VMAT1; chromaffin granule amine transporter; CGAT; 4832416I10Rik; Adrenal chromaffin granule amine transporter; MGC28683; MGC37299; Solute carrier family 18 member 1; VAT 1; VAT1; Vesicular amine transporter 1; VMAT 1; VMAT1_HUMAN; OTTHUMP00000122508; OTTHUMP00000224712; OTTHUMP00000224713; OTTHUMP00000224714; OTTHUMP00000237226; VMAT1
Cat.#:SLC18A1-2702HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC18A1, GST-tagged
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Cat.#:SLC18A1-29829THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SLC18A1
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Cat.#:SLC18A1-371HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SLC18A1
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Involved Pathway

SLC18A1 involved in several pathways and played different roles in them. We selected most pathways SLC18A1 participated on our site, such as Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC18A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Synaptic vesicle cycle
ATP6V1E1; STX2; RAB3A; UNC13A; ATP6V0A1; STXBP1; ATP6V1E2; STX3; SLC18A2; ATP6V1F
Serotonergic synapse
HTR3C; GNAI2; GNG13; CYP2C37; ALOX8; GNGT1; GABRB1; GABRB3; CYP4X1; MAOB
Dopaminergic synapse
GNB1; GNG10; PPP2R2D; CAMK2G; CALML3; PPP2R1B; AKT1; KIF5B; KCNJ5; PPP2R2B
Parkinsons disease
PARK2; NDUFA1; NDUFA3; NDUFV3; DRD1A; NDUFA2; COX8C; GPR37; NDUFV2; SLC18A2
Cocaine addiction
PRKACG; BDNF; RELA; RGS9; CREB3L4; PRKACB; SLC18A2; CREB5; SLC18A1; GRIN2B
Amphetamine addiction
CREB3L4; GRIA2; GRIN2D; CALML5; ATF4; PPP1CA; CREB3; PRKCA; CREB3L3; SLC18A1
Alcoholism
HIST1H2BD; HIST1H2AF; HIST1H2BJ; NPY; HIST1H4C; GNAI2; HDAC10; HIST1H2AB; HIST1H4D; HIST1H2AC

Protein Function

SLC18A1 has several biochemical functions, for example, drug transmembrane transporter activity, enzyme binding, monoamine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC18A1 itself. We selected most functions SLC18A1 had, and list some proteins which have the same functions with SLC18A1. You can find most of the proteins on our site.
Function
Related Protein
Function drug transmembrane transporter activity
Related Protein SLC18A3A; ABCG3; SLC47A2; SLC18A3B; SLC22A5; SLC47A1; SLC18A1; EBP; Abcb1b; ABCG2D
Function enzyme binding
Related Protein HIST1H2AN; ZFP346; CDC20; VAPB; ZFP36; PLCE1; PAWR; ADORA2A; CUTA; FAM84B
Function monoamine transmembrane transporter activity
Related Protein SLC6A3; SLC18A1; SLC6A4; SLC29A4; SLC22A1; SLC6A2; SLC18A2
Function serotonin transmembrane transporter activity
Related Protein SLC6A4A; SLC6A4; SLC18A1; SLC6A4B

SLC18A1 Related Articles

Ashe, KM; Chiu, WL; et al. Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. NEUROENDOCRINOLOGY LETTERS 32:253-258(2011).