slc23a1
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  • Official Full Name
  • solute carrier family 23 (nucleobase transporters), member 1
  • Background
  • The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • SLC23A1; solute carrier family 23 (nucleobase transporters), member 1; SLC23A2, solute carrier family 23 (nucleobase transporters), member 2; solute carrier family 23 member 1; SVCT1; YSPL3; hSVCT1; Na(+)/L-ascorbic acid transporter 1; S23A1_HUMAN; Sodium-dependent vitamin C transporter 1; Yolk sac permease-like molecule 3; sodium-dependent vitamin C transporter-1; solute carrier family 23 (nucleobase transporters), member 2; SLC23A2
Cat.#:SLC23A1-655HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human SLC23A1 Protein, GST-tagged
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Cat.#:SLC23A1-15285MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC23A1 Protein
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Cat.#:SLC23A1-5463RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC23A1 Protein
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Cat.#:SLC23A1-4238RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SLC23A1 Protein, His-tagged
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Cat.#:SLC23A1-7705ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC23A1
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Involved Pathway

SLC23A1 involved in several pathways and played different roles in them. We selected most pathways SLC23A1 participated on our site, such as Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC23A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vitamin digestion and absorption
MMACHC; TCN2; APOB; FOLH1; SLC19A3; ABCC1; RBP2; SLC46A1; SLC19A1; LRAT

Protein Function

SLC23A1 has several biochemical functions, for example, L-ascorbate:sodium symporter activity, L-ascorbic acid transporter activity, dehydroascorbic acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC23A1 itself. We selected most functions SLC23A1 had, and list some proteins which have the same functions with SLC23A1. You can find most of the proteins on our site.
Function
Related Protein
Function L-ascorbate:sodium symporter activity
Related Protein SLC23A1; SLC23A2
Function L-ascorbic acid transporter activity
Related Protein SLC23A2; SLC23A1
Function dehydroascorbic acid transporter activity
Related Protein SLC23A1; SLC2A1; SLC2A2
Function sodium ion transmembrane transporter activity
Related Protein TRAPPC10; SLC12A3; CNNM4; SLC23A1; SLC12A10.3; ASIC4; SLC12A10.2; SLC12A1; SLC12A10.1
Function sodium-dependent L-ascorbate transmembrane transporter activity
Related Protein SLC23A1; SLC23A2
Function symporter activity
Related Protein SLC25A18; SLC17A4; SLC6A16B; SLC6A19B; SLC6A6; SLC22A18; SLC1A3A; SLC1A7A; SLC16A11; SLC16A8
Function transporter activity
Related Protein SYPL; SLC25A13; PTGDSA; ATP6AP1; TIMM9; RBP5; SLC5A6A; ABCG2; RLBP1B; ABCB1

SLC23A1 Related Articles

Wade, KH; Forouhi, NG; et al. Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. AMERICAN JOURNAL OF CLINICAL NUTRITION 101:202-209(2015).
Senthilkumari, S; Talwar, B; et al. Polymorphisms in sodium-dependent vitamin C transporter genes and plasma, aqueous humor and lens nucleus ascorbate concentrations in an ascorbate depleted setting. EXPERIMENTAL EYE RESEARCH 124:24-30(2014).