slc25a15
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  • Official Full Name
  • solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
  • Background
  • This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.
  • Synonyms
  • SLC25A15; solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15; HHH, ORNT1; mitochondrial ornithine transporter 1; D13S327; ORC1; ornithine transporter 1; ORNT1; Solute carrier family 25 member 15; HHH; Ornithine transporter, mitochondrial; ORNT1_HUMAN
Cat.#:SLC25A15-2717HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC25A15, His-tagged
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Cat.#:SLC25A15-31413THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC25A15, T7 -tagged
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Cat.#:SLC25A15-1824CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLC25A15
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Involved Pathway

SLC25A15 involved in several pathways and played different roles in them. We selected most pathways SLC25A15 participated on our site, such as Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC25A15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism
ADSSL1; ELOVL1A; GYG1A; CYP4F22; AKR1C4; CHAT; MED23; ABHD14B; SLC6A7; PROZA
Metabolism of amino acids and derivatives
SLC6A7; AFMID; CDO1; BCKDK; BHMT2; SLC6A12; OAZ1A; AZIN1A; AMD2; TPH2
Metabolism of polyamines
AZIN1A; CKB; LSM1; OAZ2B; OAZ3; CKBA; SLC25A2; SAT1B; OAZ1A; SLC25A15
Urea cycle
NAGS; SLC25A15; SLC25A15A; SLC25A15B; SLC25A2

Protein Function

SLC25A15 has several biochemical functions, for example, L-ornithine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC25A15 itself. We selected most functions SLC25A15 had, and list some proteins which have the same functions with SLC25A15. You can find most of the proteins on our site.
Function
Related Protein
Function L-ornithine transmembrane transporter activity
Related Protein SLC7A1; SLC7A3A; SLC7A4; SLC25A15; SLC7A3

SLC25A15 Related Articles

Martinelli, D; Diodato, D; et al. The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome. ORPHANET JOURNAL OF RARE DISEASES 10:-(2015).
Tunali, NE; Marobbio, CMT; et al. A novel mutation in the SLC25A15 gene in a Turkish patient with HHH syndrome: Functional analysis of the mutant protein. MOLECULAR GENETICS AND METABOLISM 112:25-29(2014).