SMARCAL1
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Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
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Overview
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. -
Synonyms
SMARCAL1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP driven annealing helicase; HARP; HepA related protein; HHARP; SMARCA like Protein 1; Sucrose nonfermenting protein 2 like 1; SWI/SNF Related; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A like protein 1; HepA-related protein; SMARCA-like protein 1; ATP-driven annealing helicase; sucrose nonfermenting protein 2-like 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
SMARCAL1 involved in several pathways and played different roles in them. We selected most pathways SMARCAL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
SMARCAL1 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, annealing helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCAL1 itself. We selected most functions SMARCAL1 had, and list some proteins which have the same functions with SMARCAL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PAK7;EPHA5;LIMK1;GSK3AA;MAPK11;CSNK1G2A;MYO7AA;MAP3K3;ABCD3B |
| DNA-dependent ATPase activity | MSH6;IGHMBP2;TOP2A;ERCC6;SMARCA2;DHX36;XRCC3;MSH2;XRCC2 |
| annealing helicase activity | ZRANB3;RECQL;RAD54L;ANXA1;BLM;RECQL4;SMARCAL1 |
| helicase activity | EIF4A1A;DHX58;MOV10;DHX33;DNA2;SHPRH;MOV10B.1;EP400;MCM9 |
| protein binding | AGBL4;GRAMD3;RXRB;HDC;RIPK2;IL12A;CATSPERB;MAPK10;CENPH |
SMARCAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCAL1.
RPA2; NS1; ssdna_dt
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