SPTAN1 Protein, spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

SPTAN1

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SPTAN1

Official Full Name spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
Background Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize;the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that;associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is;specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions;including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic;encephalopathy-5. Alternate splicing results in multiple transcript variants.
Synonyms SPTAN1; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); spectrin alpha chain, brain; alpha-II spectrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; NEAS; EIEE5; SPTA2; FLJ17738; FLJ44613
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SPTAN1-30H Recombinant Human SPTAN1, His-tagged E.coli His
    Human SPTAN1-31H Recombinant Human SPTAN1, His-tagged E.coli His
    Human SPTAN1-32H Recombinant Human SPTAN1, His-tagged E.coli His
    Human SPTAN1-479H Recombinant Human SPTAN1, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Sptan1-33M Recombinant Mouse Sptan1, His-tagged E.coli His
    Mouse Sptan1-34M Recombinant Mouse Sptan1, His-tagged E.coli His
    Mouse Sptan1-35M Recombinant Mouse Sptan1, His-tagged E.coli His
    Mouse Sptan1-36M Recombinant Mouse Sptan1, His-tagged E.coli His
    Rat Sptan1-36R Recombinant Rat Sptan1, His-tagged E.coli His
    Rat Sptan1-37R Recombinant Rat Sptan1, His-tagged E.coli His
    Rat Sptan1-38R Recombinant Rat Sptan1, His-tagged E.coli His
    Rat SPTAN1-5727R Recombinant Rat SPTAN1 Protein Mammalian Cell His
    Rhesus Macaque SPTAN1-4455R Recombinant Rhesus monkey SPTAN1 Protein, His-tagged Mammalian Cell His
    Chicken SPTAN1-26C Recombinant Chicken SPTAN1, His-tagged E.coli His
    Chicken SPTAN1-27C Recombinant Chicken SPTAN1, His-tagged E.coli His
    Chicken SPTAN1-28C Recombinant Chicken SPTAN1, His-tagged E.coli His
    Chicken SPTAN1-29C Recombinant Chicken SPTAN1, His-tagged E.coli His
    Chicken SPTAN1-3422C Recombinant Chicken SPTAN1 Mammalian Cell His
    Chicken SPTAN1-468C Recombinant Chicken Spectrin, Alpha, Non-erythrocytic 1 (Alpha-fodrin), SH3 Domain E.coli N/A

    SPTAN1 involved in several pathways and played different roles in them. We selected most pathways SPTAN1 participated on our site, such as Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTAN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Tight junction CLDND; CDC42L; PRKCD; MRAS; SMYHC1; CLDN11A; EPB41; PTENA; MYH1A; F11R

    SPTAN1 has several biochemical functions, for example, actin binding, calcium ion binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTAN1 itself. We selected most functions SPTAN1 had, and list some proteins which have the same functions with SPTAN1. You can find most of the proteins on our site.

    Function Related Protein
    actin binding TWF1B; MYO19; VMHCL; MSRB2; FHL3; MTSS1LA; SPTBN2; CAP2; GC; CAPZA1
    calcium ion binding MYL2B; MMP24; CDH19; ANXA6; NCAN; MYL1; MYL3; PCDH2AA3; SYTL3; PCDHGC3
    calmodulin binding ADD3; KCNH1; MARCKSL1A; SPTBN1; MYH10; USP6; MYO5B; IQCB1; MAPKAPK2A; REM1
    protein binding GPRASP1; EFNA1; ZEB1; FAM168A; ELMO1; C11orf65; GPR77; GLMN; NEDD4; DCC
    protein heterodimerization activity TAS1R3; MID1; KCNN1; BDKRB2; BNIP3L; CA; H2AFB1; ZHX3; P4HB; SYCP2
    spectrin binding ADD1; MYO10; EPB41; DCTN2; KIF3A; GNB1; GBP1; USH1G; SPTAN1; UNC13A
    structural constituent of cytoskeleton BFSP1; TUBGCP2; NDC80; KRT20; TUBA8L; ACTL6B; TUBA8; INA; TUBA1A; NGS

    SPTAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTAN1.

    MLH1; FANCC; EVL; FANCG; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate

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