ST14 Protein, suppression of tumorigenicity 14 (colon carcinoma)


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Official Full Name suppression of tumorigenicity 14 (colon carcinoma)
Background The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
Synonyms ST14; suppression of tumorigenicity 14 (colon carcinoma); HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14; suppressor of tumorigenicity 14 protein; prostamin; serine protease 14; serine protease TADG-15; membrane-type serine protease 1; tumor associated differentially expressed gene 15 protein; tumor-associated differentially-expressed gene 15 protein; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • Met
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ST14-256H Recombinant Human ST14, His-tagged E.coli His
    Human ST14-2977H Recombinant Human ST14, His-tagged E.coli His
    Human ST14-30315TH Recombinant Human ST14 Wheat Germ N/A
    Human ST14-31173TH Recombinant Human ST14 Wheat Germ N/A
    Human ST14-742H Recombinant Human ST14 Protein, Met & His-tagged E.coli Met/His
    Mouse ST14-16060M Recombinant Mouse ST14 Protein Mammalian Cell His
    Mouse St14-210M Recombinant Mouse St14, His-tagged E.coli His
    Mouse St14-653M Recombinant Mouse St14 Protein, Met & His-tagged E.coli Met/His

    ST14 involved in several pathways and played different roles in them. We selected most pathways ST14 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MicroRNAs in cancer CDC25A; FSCN1; CYP24A1; RHOA; FOXP1; BCL2; Pdgfa&Pdgfb; VIM; BAK1; MAP2K1

    ST14 has several biochemical functions, for example, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST14 itself. We selected most functions ST14 had, and list some proteins which have the same functions with ST14. You can find most of the proteins on our site.

    Function Related Protein
    serine-type endopeptidase activity KLK15; IMMP1L; FAP; PROZ; PRSS48; PROCA; TYSND1; KLK13; LOC100686744; KLK2
    serine-type peptidase activity PRSS59.2; PRSS44; MCPT1; IRBP; DPP7; PRSS42; KLK15; FURINB; TMPRSS4B; ELA2L

    ST14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST14 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST14.

    bpt1_bovin; MST1; IGFBP7; RGS16; CHEK2; TGFB1; APC; AKT1; PHB; CDKN2C; NOTCH2; RAD51; CASP8; STK11

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