STC2

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STC2

Official Full Name stanniocalcin 2
Background This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
Synonyms STC2; stanniocalcin 2; stanniocalcin-2; STC 2; STC-related protein; stanniocalcin-related protein; STC-2; STCRP
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Tag :
    • DDK
    • His
    • Fc
    • Flag
    • Myc
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STC2-142H Recombinant Human Stanniocalcin 2, Flag-tagged HEK293 Flag
    Human STC2-187H Recombinant Human STC2, His tagged Human Cell Fc/His
    Human STC2-201H Recombinant Human Stanniocalcin 2, T7-tagged E.coli T7
    Human STC2-2895H Recombinant Human STC2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human STC2-30113TH Recombinant Human STC2, T7 -tagged E.coli T7
    Human STC2-30114TH Recombinant Human STC2, FLAG-tagged Flag
    Human STC2-373H Recombinant Human STC2 Protein, His-tagged E.coli His
    Human STC2-3746H Recombinant Human STC2 protein, Flag-tagged HEK293 Flag
    Human STC2-519H Recombinant Human STC2 Protein, DDK/His-tagged HEK293 DDK/His
    Human STC2-7631H Recombinant Human STC2, His-tagged E.coli N/A
    Human STC2-849HCL Recombinant Human STC2 cell lysate Human Cell N/A
    Human STC2-8603H Recombinant Human STC2, Fc tagged Human Cell N/A
    Mouse STC2-16118M Recombinant Mouse STC2 Protein Mammalian Cell His
    Rat STC2-5784R Recombinant Rat STC2 Protein Mammalian Cell His

    STC2 involved in several pathways and played different roles in them. We selected most pathways STC2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with STC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    STC2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by STC2 itself. We selected most functions STC2 had, and list some proteins which have the same functions with STC2. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding LGALS9; PPP3CA; MLEC; NOXA1; CASC3; POR; ABCD1; VAPB; PDE4DIP; UGT1A7
    heme binding CYP2K18; CYP1D1; CYP1A4; HBAA1; NENF; CYP2A12; CYGB1; HBG2; FA2H; CYP2P7
    hormone activity SST2; RLN3A; NMB; INHA; PRL2C2; GIP; LEPB; UTS2; CSH1; SST3
    protein homodimerization activity SMAD1; BHLHE40; QPRT; G6PDX; GRM6; S100A5; TPD52L2; RNF17; ADD2; CLN6

    STC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STC2.

    ADAM11; AIFM1; POLR2C; PTN; PEBP1; ARRB2; PPP1R8; ARHGEF40; POLR3F; EIF2B3; CARHSP1

    Miyazaki, S; Kikuchi, H; et al. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. INTERNATIONAL JOURNAL OF CANCER 135:295-307(2014).
    Kashyap, MK; Pawar, HA; et al. Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma. CANCER BIOMARKERS 12:1-9(2012).

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