stc2
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  • Official Full Name
  • stanniocalcin 2
  • Background
  • This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
  • Synonyms
  • STC2; stanniocalcin 2; stanniocalcin-2; STC 2; STC-related protein; stanniocalcin-related protein; STC-2; STCRP
Cat.#:STC2-2895HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STC2 Protein, MYC/DDK-tagged
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Cat.#:STC2-373HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STC2 Protein, His-tagged
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Cat.#:STC2-142HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human Stanniocalcin 2, Flag-tagged
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Cat.#:STC2-187HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human STC2, His tagged
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Cat.#:STC2-201HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Stanniocalcin 2, T7-tagged
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Cat.#:STC2-30113THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STC2, T7 -tagged
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Cat.#:STC2-30114THTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human STC2, FLAG-tagged
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Cat.#:STC2-3746HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human STC2 protein, Flag-tagged
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Cat.#:STC2-519HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human STC2 Protein, DDK/His-tagged
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Cat.#:STC2-7631HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STC2, His-tagged
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Cat.#:STC2-8603HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human STC2, Fc tagged
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Cat.#:STC2-16118MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STC2 Protein
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Cat.#:STC2-5784RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STC2 Protein
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Cat.#:STC2-849HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human STC2 cell lysate
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Protein Function

STC2 has several biochemical functions, for example, enzyme binding, heme binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by STC2 itself. We selected most functions STC2 had, and list some proteins which have the same functions with STC2. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein SUPT5H; CAV1; NPC2; TSPAN14; FAM84B; HSPA2; ZFP36; GSTM7; TRP53; PARK2
Function heme binding
Related Protein CYBA; PXDN; PTGS2A; CYP46A1.3; HBG2; CYP1A2; CYP2C54; CYB5A; CYB5D2; CYP2C9
Function hormone activity
Related Protein GUCA2A; IGF1; HAMP; PYY; URP2; CHGB; GCGB; EDN2; LRSAM1; STC1L
Function protein homodimerization activity
Related Protein HM13; DMRT2A; TERF1; KIAA1804; GDNFA; SHMT1; TPR; FAP; FBXO4; DEM1

Interacting Protein

STC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STC2.
ADAM11; AIFM1; POLR2C; PTN; PEBP1; ARRB2; PPP1R8; ARHGEF40; POLR3F; EIF2B3; CARHSP1

STC2 Related Articles

Miyazaki, S; Kikuchi, H; et al. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. INTERNATIONAL JOURNAL OF CANCER 135:295-307(2014).
Kashyap, MK; Pawar, HA; et al. Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma. CANCER BIOMARKERS 12:1-9(2012).