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STK36

Official Full Name

serine/threonine kinase 36
Overview

This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants.
Synonyms

STK36; serine/threonine kinase 36; serine/threonine kinase 36 (fused homolog, Drosophila); serine/threonine-protein kinase 36; FU; fused homolog (Drosophila); KIAA1278; Fused homolog; Serine/threonine kinase 36, fused homolog; OTTHUMP00000164096; OTTHUMP00000164097; OTTHUMP00000206456;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
Mammalian Cell
Sf9 Insect Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	STK36-264H	Active Recombinant Human STK36, GST-tagged	Sf9 Insect Cell	GST	Inquiry
Human	STK36-1714HCL	Recombinant Human STK36 cell lysate		N/A	Inquiry
Mouse	STK36-16147M	Recombinant Mouse STK36 Protein	Mammalian Cell	His	Inquiry
Mouse	STK36-8811M	Recombinant Mouse STK36 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	STK36-8811M-B	Recombinant Mouse STK36 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	STK36-4781Z	Recombinant Zebrafish STK36	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
STK36 Related Articles

STK36 involved in several pathways and played different roles in them. We selected most pathways STK36 participated on our site, such as Hedgehog signaling pathway, Pathways in cancer, Basal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hedgehog signaling pathway	GLI2B;CSNK1G3;WNT10B;RAB23;DYRK1AA;WNT6;GAS1A;WNT8A;WNT11R
Pathways in cancer	PGF;SUFU;LAMB1;NCOA4;FGF22;CTBP2;TPM3;BRAF;BCL2
Basal cell carcinoma	APC2;WNT3A;GSK3B;WNT3;WNT2B;WNT1;FZD3;FZD9;WNT11

STK36 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK36 itself. We selected most functions STK36 had, and list some proteins which have the same functions with STK36. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	BAZ1B;IQCA1;PAPOLA;ATAD5;LRRK2;NADSYN1;Abca2;UCK2;CDK17
magnesium ion binding	INPP1;OPA1;NME1;PRPS1A;WEE2;STK38L;TREX2;PINK1;PAPOLA
protein binding	VAMP3;COMMD10;STXBP4;ELMO2;LAMA4;CRYGC;KIF13B;RSPO2;ORAI3
protein serine/threonine kinase activity	NUAK1;CDK15;STK38;SNRK;SLK;AKT1;OXSR1B;DYRK1B;TLK1B
transcription factor binding	HDAC2;HDAC5;MYBBP1A;DDIT3;NKX3-1;PDCD11;PRKDC;KAT2A;ZBTB49

STK36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK36 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK36.

GLI1; GLI3; SUFU; ARMC6; Gli2; FRMPD4; MAST2; CLNK; CDK5RAP2

Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).