strada
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  • Official Full Name
  • STE20-related kinase adaptor alpha
  • Background
  • The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a pseudokinase. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
  • Synonyms
  • STRADA; STE20-related kinase adaptor alpha; STE20-related kinase adapter protein alpha; LYK5; NY BR 96; STE20 like pseudokinase; Stlk; STRAD; STRAD alpha; protein kinase LYK5; STE20-like pseudokinase; serologically defined breast cancer antigen NY-BR-96
Cat.#:STRADA-4560HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human STRADA Protein, GST-tagged
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Cat.#:STRADA-229HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STRADA, His-tagged
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Cat.#:STRADA-449HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STRADA Protein, His-tagged
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Cat.#:STRADA-5804RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STRADA Protein
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Cat.#:STRADA-2068CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STRADA
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Cat.#:STRADA-10280ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STRADA
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Cat.#:STRADA-1041HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human STRADA cell lysate
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Involved Pathway

STRADA involved in several pathways and played different roles in them. We selected most pathways STRADA participated on our site, such as mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STRADA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mTOR signaling pathway
PRKAA2; STRADA; RPS6KA3; MLST8; PIK3CG; TSC1A; PIK3R5; EIF4E1C; IKBKB; INS2
AMPK signaling pathway
PPP2R1A; EEF2K; RAB2A; PPP2R1B; AKT2; PIK3CA; RAB10; FBP1; CPT1A; MLYCD

Protein Function

STRADA has several biochemical functions, for example, ATP binding, NOT Rac GTPase binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STRADA itself. We selected most functions STRADA had, and list some proteins which have the same functions with STRADA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SIK2A; EPRS; TRPM6; PIK3C2B; ATP1A1A.2; MADD; CSNK2A2A; KIF23; ACSM5; TOP2B
Function NOT Rac GTPase binding
Related Protein STRADB; STRADA
Function kinase binding
Related Protein RPS3; TOLLIP; LDHB; CEBPB; JAKMIP2; PRKCD; GFAP; MOB4; ATF5; CDC37
Function protein binding
Related Protein MLLT1; HIST1H4H; DSCC1; FHOD1; C10orf35; BOP1; C16orf87; MED31; P2RY6; LRRC20
Function protein kinase activator activity
Related Protein STRADA; FGF13; AGAP2; PRKAG2; DAXX; DUSP19; GPRC5B; NKX3-1; FAM58A; TOM1L1
Function NOT protein kinase activity
Related Protein HSPB8; TRIB1; TRIB2; STRADB; MLKL; STRADA; PXK
Function protein serine/threonine kinase activator activity
Related Protein CAB39; CDK5R1; CALM3; LTF; STK4; IGF2; FAM20A; SPRY2; MAP2K1; PARP16
Function NOT protein serine/threonine kinase activity
Related Protein SNX15; FAM20A; STRADA; STRADB

Interacting Protein

STRADA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STRADA here. Most of them are supplied by our site. Hope this information will be useful for your research of STRADA.
STK11; CAB39

STRADA Related Articles

Veleva-Rotse, BO; Smart, JL; et al. STRAD pseudokinases regulate axogenesis and LKB1 stability. NEURAL DEVELOPMENT 9:-(2014).
Sugden, PH; McGuffin, LJ; et al. SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. BIOCHEMICAL JOURNAL 454:13-30(2013).