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Official Full Name sulfatase 2
Background Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and;are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate;groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for;signaling molecules (Dai et al., 2005 (PubMed 16192265)).
Synonyms SULF2; sulfatase 2; extracellular sulfatase Sulf-2; HSULF 2; KIAA1247; SULF 2; Extracellular sulfatase Sulf 2; HSulf-2; HSulf2; SULF2_HUMAN
    • Species :
    • Flavobacterium heparinum
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SULF2-1358HCL Recombinant Human SULF2 293 Cell Lysate HEK293 N/A
    Human SULF2-1359HCL Recombinant Human SULF2 293 Cell Lysate HEK293 N/A
    Human SULF2-3045H Recombinant Human SULF2, GST-tagged E.coli GST
    Human SULF2-665H Recombinant Human SULF2 Protein, His/GST-tagged E.coli His/GST
    Human SULF2-963H Recombinant Human SULF2 Mammalian Cell His
    Mouse SULF2-16218M Recombinant Mouse SULF2 Protein Mammalian Cell His
    Mouse Sulf2-666M Recombinant Mouse Sulf2 Protein, His-tagged E.coli His
    Flavobacterium heparinum SULF2-02F Native Flavobacterium heparinum 2-O-Sulfatase N/A

    SULF2 involved in several pathways and played different roles in them. We selected most pathways SULF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SULF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    SULF2 has several biochemical functions, for example, N-acetylglucosamine-6-sulfatase activity, arylsulfatase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SULF2 itself. We selected most functions SULF2 had, and list some proteins which have the same functions with SULF2. You can find most of the proteins on our site.

    Function Related Protein
    N-acetylglucosamine-6-sulfatase activity GNSB; SULF2; GNSA; GNS; SULF1
    arylsulfatase activity ARSG; ARSK; ARSF; ARSE; ARSB; ARSJ; ARSH; SULF1; ARSD; ARSI
    calcium ion binding FREM2; GUCA1B; SLIT1A; ANXA11A; PLA2G4B; PPP2R3A; EGFL8; CAPN12; CETN4; FAT4

    SULF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SULF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SULF2.


    Singer, MS; Phillips, JJ; et al. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. CLINICA CHIMICA ACTA 440:72-78(2015).
    Joy, MT; Vrbova, G; et al. Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro. EXPERIMENTAL NEUROLOGY 263:150-160(2015).
    Alhasan, AA; Spielhofer, J; et al. Role of 6-O-Sulfated Heparan Sulfate in Chronic Renal Fibrosis. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20295-20306(2014).
    Lui, NS; van Zante, A; et al. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ OPEN 2:-(2012).

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