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TAP1

  • Official Full Name

    transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

  • Overview

    CRTAP is found in articular chondrocytes and is expressed in a variety of other tissues. Defects in CRTAP are the cause of osteogenesis imperfecta type 7 (OI-7). OI is a connective tissue disorder characterized by bone fragility and low bone mass. OI-7 is an autosomal recessive form of OI.
  • Synonyms

    TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); APT1; PSF1; ABC17; ABCB2; RING4; TAP1N; D6S114E; FLJ26666; FLJ41500; TAP1*0102N; ABC 17; ATP binding cassette sub family B (MDR/TAP) member 2; ATP binding cassette transporter; Peptide transporter PSF 1; Transporter 1 ATP binding cassette sub family B (MDR/TAP); Peptide supply factor 1; Really interesting new gene 4 protein2; PSF-1; antigen peptide transporter 1; ABC transporter, MHC 1; transporter, ATP-binding cassette, major histocompatibility complex, 1Y3; transporter associated with antigen processing;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TAP1-7882H Recombinant Human TAP1 protein, His & T7-tagged E.coli His/T7 Tyr525~Glu808 (Accession # Q03518)
Human TAP1-3512H Recombinant Human TAP1, His-tagged E.Coli or Yeast His 808
Human TAP1-3113H Recombinant Human TAP1, GST-tagged E.coli GST C-term-300aa
Human TAP1-1254HCL Recombinant Human TAP1 293 Cell Lysate HEK293 N/A
Human TAP1-6821HF Recombinant Full Length Human TAP1 Protein, GST-tagged In Vitro Cell Free System GST 808 amino acids
Human TAP1-6397H Recombinant Human TAP1 Protein (Tyr525-Glu808), N-His tagged E.coli N-His Tyr525-Glu808
Human TAP1-675H Recombinant Human TAP1 Protein, GST-tagged Wheat Germ GST 1-808 aa
Rat Tap1-3511R Recombinant Rat Tap1, His-tagged E.Coli or Yeast His 725
Chicken TAP1-3878C Recombinant Chicken TAP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TAP1 Related Articles

TAP1 involved in several pathways and played different roles in them. We selected most pathways TAP1 participated on our site, such as ABC transporters, Phagosome, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC transportersABCB6;ABCC5;ABCA1B;CFTR;ABCD4;ABCG1;ABCG2;ABCB11;ABCD3A
PhagosomeFCGR2C;STX7;HLA-A;DYNC1LI2;RAB5AB;BLB1;RAB7;CD14;TUBA7L
Antigen processing and presentationHSPA2;IFNG;CANX;PSME2;RFX5;NFYA;KLRC2;CD8B;HLA-G
Herpes simplex infectionCFP;IFIH1;HCFC1B;IFNG;MAPK8;Casp3;BLA;IL12BA;PPP1CC
Primary iPTPRC;BLNK;CD79A;CD8A;CD40LG;CD19;BTK;IKBKG;AICDA
nodeficiencyPTPRC;IKBKG;CD8A;ZAP70;ICOS;RFX5;TNFRSF13B;RAG1;TAP2

TAP1 has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by TAP1 itself. We selected most functions TAP1 had, and list some proteins which have the same functions with TAP1. You can find most of the proteins on our site.

Function Related Protein
ADP bindingADCK3;GLUD1;ABCG1;GLUD2;PRKAG1;VCP;PRPS2;CYB5R3;ACTA1
ATP bindingMLH3;LARS;SUCLG1;CSF1R;VMHCL;PIP5K2;RAD50;ERBB4A;PRKACBA
ATPase activity, coupled to transmembrane movement of substancesABCG8;IPO8;ABCG2D;ABCB4;ABCB10;ABCC2;ABCD1;ABCB6A;ABCB5
MHC class I protein bindingDERL1;ATP5A1;CD8A;HLA-E;TAPBP;LILRB2;PILRB;CD8B;PILRB2
MHC class Ib protein bindingTAP2;LILRB2;TAP1
TAP1 bindingHLA-F;TAPBP;TAP2;TAP1
TAP2 bindingTAP1;TAPBP;HLA-F
peptide antigen bindingMHC1UBA;MHC1UKA;H2-AA;H2-AB1;MHC1UIA;TAPBP;MHC1UHA;MHC1UDA;HLA-DRB3
contributes_to peptide transporter activityTAP2;TAP1
peptide transporter activityTAP1;DISP1
peptide-transporting ATPase activityTAP1;ABCB9
protein bindingUSP1;GSTO1;TBCA;MATN3;DDX58;VAMP7;FPR1;CRHR1;ID3
protein heterodimerization activityKCNH1;H2AFV;SNX5;TPD52;AHR;P4HB;DRD1;INHA;H2-AA
protein homodimerization activityVEGFA;ABCG2;S100A6;ZNF174;SDCBP2;CBX5;GM5506;DRD2;TRIM8
tapasin bindingTAP1;TAP2

TAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAP1.

TAP2; TAPBP

Tuncel, J; Haag, S; et al. Natural Polymorphisms in Tap2 Influence Negative Selection and CD4 : CD8 Lineage Commitment in the Rat. PLOS GENETICS 10:-(2014).
Gameiro, SR; Jammeh, ML; et al. Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing. ONCOTARGET 5:403-416(2014).
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