Recombinant Human TAP1 Protein, GST-tagged

• Cat.No.: TAP1-675H
• Product Overview: Recombinant Human TAP1 Full-Length ORF Protein (1-808 aa) is produced by Wheat Germ (in vitro) expression system. This protein is fused with a GST tag at the N-terminal.

Specification

• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 113.6 kDa
• Protein length: 1-808 aa
• AA Sequence: MAELLASAGSACSWDFPRAPPSFPP PAASRGGLGGTRSFRPHRGAESPRP GRDRDGVRVPMASSRCPAPRGCRCL PGASLAWLGTVLLLLADWVLLRTAL PRIFSLLVPTALPLLRVWAVGLSRW AVLWLGACGVLRATVGSKSENAGAQ GWLAALKPLAAALGLALPGLALFRE LISWGAPGSADSTRLLHWGSHPTAF VVSYAAALPAAALWHKLGSLWVPGG QGGSGNPVRRLLGCLGSETRRLSLF LVLVVLSSLGEMAIPFFTGRLTDWI LQDGSADTFTRNLTLMSILTIASAV LEFVGDGIYNNTMGHVHSHLQGEVF GAVLRQETEFFQQNQTGNIMSRVTE DTSTLSDSLSENLSLFLWYLVRGLC LLGIMLWGSVSLTMVTLITLPLLFL LPKKVGKWYQLLEVQVRESLAKSSQ VAIEALSAMPTVRSFANEEGEAQKF REKLQEIKTLNQKEAVAYAVNSWTT SISGMLLKVGILYIGGQLVTSGAVS SGNLVTFVLYQMQFTQAVEVLLSIY PRVQKAVGSSEKIFEYLDRTPRCPP SGLLTPLHLEGLVQFQDVSFAYPNR PDVLVLQGLTFTLRPGEVTALVGPN GSGKSTVAALLQNLYQPTGGQLLLD GKPLPQYEHRYLHRQVAAVGQEPQV FGRSLQENIAYGLTQKPTMEEITAA AVKSGAHSFISGLPQGYDTEVDEAG SQLSGGQRQAVALARALIRKPCVLI LDDATSALDANSQLQVEQLLYESPE RYSRSVLLITQHLSLVEQADHILFL EGGAIREGGTHQQLMEKKGCYWAMV QAPADAPE
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [ Homo sapiens ]
• Official Symbol: TAP1
• Synonyms: TAP1; ABCB2; D6S114E; PSF1; RING4; APT1; ABC17; PSF-1; TAP1N; TAP1*0102N; FLJ26666; FLJ41500
• Gene ID: 6890
• mRNA Refseq: NM_000593
• Protein Refseq: NP_000584
• MIM: 170260
• UniProt ID: Q03518