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TBP

  • Official Full Name

    TATA binding protein

  • Overview

    General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
  • Synonyms

    GTF2D,GTF2D1,HDL4,MGC117320,MGC126054,MGC126055,SCA17,TATA binding factor,TATA box factor,TATA sequence binding protein,TATA sequence-binding protein,TATA-binding factor,TATA-box binding protein N-terminal domain,TATA-box factor,TATA-box-binding protein,TBP,TBP_HUMAN,TFIID,Transcription initiation factor TFIID TBP subunit; TATA; binding protein TBP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TBP-1169H Active Recombinant Human TATA Box Binding Protein, GST-tagged E.coli GST
Human TBP-30154TH Recombinant Human TBP, His-tagged E.coli His
Human TBP-1210HCL Recombinant Human TBP 293 Cell Lysate HEK293 N/A
Human TBP-6401H Recombinant Human TBP Protein (Met1-Thr338), N-His tagged E.coli N-His Met1-Thr338
Mouse Tbp-1823M Recombinant Mouse Tbp protein, His & T7-tagged E.coli His/T7 Pro8~Thr316 (Accession # P29037)
Mouse TBP-16517M Recombinant Mouse TBP Protein Mammalian Cell His
Mouse TBP-9051M Recombinant Mouse TBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TBP-9051M-B Recombinant Mouse TBP Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey TBP-1005C Recombinant Cynomolgus TBP Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey TBP-748C Recombinant Cynomolgus Monkey TBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey TBP-748C-B Recombinant Cynomolgus Monkey TBP Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TBP-10448Z Recombinant Zebrafish TBP Mammalian Cell His
Chicken TBP-6660C Recombinant Chicken TBP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TBP Related Articles

TBP involved in several pathways and played different roles in them. We selected most pathways TBP participated on our site, such as Basal transcription factors, Huntingtons disease, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Basal transcription factorsGTF2H2C_2;GTF2F2B;ERCC3;GTF2B;GTF2F1;TAF4B;GTF2F2;TAF7L;TAF8
Huntingtons diseaseDNAH5;ATP5C1;POLR2L;POLR2F;NDUFA11;NDUFA9;COX7A2;POLR2H;NDUFB1
HTLV-I infectionBUB3;XPO1;BUB1B;PTTG1;ANAPC5;LCK;PPP3CC;TNF;POLE2
Herpes simplex infectionHLA-DRB1;Ifna15;MHC2DAB;TBK1;PVRL2;IL12B;NXF1;PKZ;HNRPKL
Epstein-Barr virus infectionCCNA1;CCNA2;POLR2I;PLCG1;SFPI1;SNW1;PSMD2;RIPK1;HDAC5
Viral carcinogenesisMAD1L1;HLA-G;SRF;HIST1H4K;GRB2;HRAS;YWHAZ;MRPS18B;SCIN

TBP has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBP itself. We selected most functions TBP had, and list some proteins which have the same functions with TBP. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingFOSL2;TFAP2E;NDN;FUBP3;E2F8;NACC2;MITFA;FEZF1;TLX1
RNA polymerase II repressing transcription factor bindingRBPJ;GTF2A2;MTA1;PROL1;RBBP8;BBS2;TBX5A;MIXL1;HDAC1
enzyme bindingNFKBIA;MARCH6;SCNM1;PRKDC;HDAC2;TMBIM6;PAWR;MDM2;TRIO
protein bindingRAPGEF4;IRF6;PEX19;GBAS;LOXL3;PSG5;SNAP23;GAP43;SNAI2
repressing transcription factor bindingNOC2L;GMNN;HDAC7;HDAC9;TLE4;KAT5;SRI;HDAC7A;PRDM5
transcription factor activity, sequence-specific DNA bindingTP53;ZSCAN4D;TEFA;ZSCAN4;IRF5;CREM;IRF4A;MECP2;PLAGL2
transcription factor bindingHEY2;ESRRB;NLRP3;FOXA3;EPAS1;GATA3;EPN1;HMGA2;SOST
transcription regulatory region DNA bindingTFAP2A;MEN1;MEF2C;GFI1;TCF7L1A;NKX2-5;ARID4A;SALL1;SOX2

TBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TBP.

lt_sv40; TAF1; TAF5; TAF1B

Jackisch, C; Welslau, M; et al. Impact of trastuzumab treatment beyond disease progression for advanced/metastatic breast cancer on survival - Results from a prospective, observational study in Germany. BREAST 23:603-608(2014).
Voss, C; Schmitt, B; et al. A novel, non-radioactive eukaryotic in vitro transcription assay for sensitive quantification of RNA polymerase II activity. BMC MOLECULAR BIOLOGY 15:-(2014).
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