tbl1x
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  • Official Full Name
  • transducin (beta)-like 1X-linked
  • Background
  • The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
  • Synonyms
  • TBL1X; transducin (beta)-like 1X-linked; TBL1, transducin (beta) like 1; F-box-like/WD repeat-containing protein TBL1X; EBI; transducin beta-like protein 1X; transducin-beta-like protein 1, X-linked; TBL1; SMAP55
Cat.#:TBL1X-99HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TBL1X protein, His-tagged
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Cat.#:TBL1X-1004CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TBL1X Protein, His-tagged
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Cat.#:TBL1X-3951CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TBL1X
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Cat.#:TBL1X-5323ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TBL1X
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Cat.#:TBL1X-1214HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TBL1X 293 Cell Lysate
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Involved Pathway

TBL1X involved in several pathways and played different roles in them. We selected most pathways TBL1X participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBL1X were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
CAMK2G1; TBL1X; BAMBIA; CXXC4; GPC4; FZD7A; WNT9A; CSNK1A1L; PPARD; WNT2BA

Protein Function

TBL1X has several biochemical functions, for example, beta-catenin binding, histone binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBL1X itself. We selected most functions TBL1X had, and list some proteins which have the same functions with TBL1X. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein CHD8; EP300; GLI3; CTNNA1; AXIN1; BTRC; TCF7L2; SHROOM2; FAM123B; CTNNA3
Function histone binding
Related Protein HIST2H3C; NCAPD2; USP49; PRKCBP1L; PRKCB; HIST1H4H; CTSL2; DEK; HIST1H3E; DTX3L
Function protein C-terminus binding
Related Protein MRE11A; PEX12; EP300; MIF4GD; VTA1; DLG3; PPP2CB; TCF4; SLC9A3R2; SHANK3
Function protein binding
Related Protein NUMB; LCORL; ARR3; NKX3; IL2RG; ZNF259; RAD9; FHL3; LIMK2; SNAP25
Function protein domain specific binding
Related Protein HMGB2; SHC4; WNT3; CEP68; ICAL1; PLXND1; IL1B; XPA; RAPGEF3; WNT5A
Function transcription corepressor activity
Related Protein HDAC3; RUNX1T1; NRIP1; SMYD1; TOB1; APEX1; CBFA2T2; CBFA2T3; ELK3; FEV
Function transcription factor binding
Related Protein DRG1; SIRT2; ARHGEF2; NBN; SMARCA4; FOXF2; H2-AB1; DDX3X; HDAC5; MED1
Function transcription regulatory region DNA binding
Related Protein BRD7; WNT1; ARRB1; TFAP2A; CARM1; SMAD7; MLL1; HIVEP3; TCF7L1A; GATA5

Interacting Protein

TBL1X has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBL1X here. Most of them are supplied by our site. Hope this information will be useful for your research of TBL1X.
HDAC3; TINF2; CTNNB1; CACYBP; DLX3; HP; TERF1; KHDRBS1; DNAJB4; HDAC7; TBL1XR1; HDAC5