tbp
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  • Official Full Name
  • TATA binding protein
  • Background
  • General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
  • Synonyms
  • GTF2D,GTF2D1,HDL4,MGC117320,MGC126054,MGC126055,SCA17,TATA binding factor,TATA box factor,TATA sequence binding protein,TATA sequence-binding protein,TATA-binding factor,TATA-box binding protein N-terminal domain,TATA-box factor,TATA-box-binding protein,TBP,TBP_HUMAN,TFIID,Transcription initiation factor TFIID TBP subunit; TATA; binding protein TBP
Cat.#:TBP-1169HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TATA Box Binding Protein, GST-tagged
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Cat.#:TBP-30154THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TBP, His-tagged
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Cat.#:TBP-16517MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TBP Protein
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Cat.#:Tbp-1823MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tbp protein, His & T7-tagged
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Cat.#:TBP-1005CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TBP Protein, His-tagged
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Cat.#:TBP-6660CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TBP
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Cat.#:TBP-10448ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TBP
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Cat.#:TBP-1210HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TBP 293 Cell Lysate
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Involved Pathway

TBP involved in several pathways and played different roles in them. We selected most pathways TBP participated on our site, such as Basal transcription factors, Huntingtons disease, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Basal transcription factors
GTF2A1L; GTF2E1; GTF2F2; TAF3; GTF2A2; GTF2IRD1; TAF2; GTF2B; GTF2H2; TAF7L
Huntingtons disease
SP1; SLC25A31; ATP5A1; DNAI1; POLR2J; NDUFA7; UQCRQ; DNAI2; COX6A2; HIP1
HTLV-I infection
ANAPC7; LTBR; H2-AA; STAT5A; WNT7B; TNFRSF13C; ATF1; BAX; ELK1; NFYB
Herpes simplex infection
IFNA14; STAT1B; DAXX; IFNPHI3; MHC2DEB; SRSF5; SOCS3; BF1; TRP53; IL1B
Epstein-Barr virus infection
RBPJL; ENTPD8; GSK3B; TBPL2; HLA-DPB1; HDAC2; PSMC1; AKT2; Fcer2a; NFKB1
Viral carcinogenesis
PIK3CG; GTF2H2C; HIST3H2BB-PS; HLA-B; KRAS; CCNE2; HDAC9; ACTN2; HIST1H4L; YWHAH

Protein Function

TBP has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBP itself. We selected most functions TBP had, and list some proteins which have the same functions with TBP. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein RFX3; RUNX2; NFIB; GATA4; NKX2-5; PBX1; EN1; ATF7; PAX5; PYDC3
Function RNA polymerase II repressing transcription factor binding
Related Protein SP1; RBPJ; STAT3; TTC8; HDAC1; BBS10; RBBP8; PPARA; BBS1; GTF2A2
Function enzyme binding
Related Protein ERN1; HSPA6; TULP3; CAD; TBP; MST1R; GSTM2; PPARG; AKIRIN2; ZNF346
Function protein binding
Related Protein AHCYL1; PARD3; E2F5; CNOT4; KRTAP9-2; LAIR1; GLI2; TOP1; PIK3IP1; SLC25A10
Function repressing transcription factor binding
Related Protein HDAC7A; MAGEA2; CTNNB1; MAGEA2B; GMNN; HDAC9; EIF4E; HHEX; MYC; NFYB
Function transcription factor activity, sequence-specific DNA binding
Related Protein STAT6; NR5A2; POU2F1B; POU4F2; SOX11A; FOXA3; CREB5; FOXF2A; SALL4; SIX1A
Function transcription factor binding
Related Protein ATG7; TFDP1A; NFATC4; TRIM6; ZFPM2; E2F4; SP100; EPN1; CDK9; ZFPM1
Function transcription regulatory region DNA binding
Related Protein H2AFY2; YY1; SALL4; FOXH1; PROX1; TCF7; FOXA1; RCOR1; XRCC6; TA

Interacting Protein

TBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TBP.
lt_sv40; TAF1; TAF5; TAF1B

TBP Related Articles

Jackisch, C; Welslau, M; et al. Impact of trastuzumab treatment beyond disease progression for advanced/metastatic breast cancer on survival - Results from a prospective, observational study in Germany. BREAST 23:603-608(2014).
Voss, C; Schmitt, B; et al. A novel, non-radioactive eukaryotic in vitro transcription assay for sensitive quantification of RNA polymerase II activity. BMC MOLECULAR BIOLOGY 15:-(2014).