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TBPL1

Official Full Name

TBP-like 1
Overview

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.
Synonyms

TBPL1; TBP-like 1; TATA box-binding protein-like protein 1; STUD; TLF; TLP; TRF2; 21kDa TBP like protein; Second TBP of unique DNA; TATA box binding protein like protein 1; TATA box binding protein-related factor 2; TBP like 1; TBP like protein; TBP related factor 2; TBP-like factor; TBP-like protein 1; TBP-related protein; TBP-related factor 2; 21 kDa TBP-like protein; 21-kDA TBP-like protein; second TBP of unique DNA protein; TATA box-binding protein-related factor 2; MGC:8389; MGC:9620;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Cynomolgus Monkey
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TBPL1-3136H	Recombinant Human TBPL1, GST-tagged	E.coli	GST	1-186aa	$319 / 25ug
Human	TBPL1-7114H	Recombinant Human TBPL1, His-tagged	E.coli	His	1-186aa	Inquiry
Human	TBPL1-1209HCL	Recombinant Human TBPL1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TBPL1-3553H	Recombinant Human TBPL1 protein, His-SUMO-tagged	E.coli	His-SUMO	1-185aa	Inquiry
Mouse	TBPL1-16518M	Recombinant Mouse TBPL1 Protein	Mammalian Cell	His		Inquiry
Mouse	TBPL1-9052M-B	Recombinant Mouse TBPL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	TBPL1-9052M	Recombinant Mouse TBPL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Cynomolgus Monkey	TBPL1-1006C	Recombinant Cynomolgus TBPL1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Cynomolgus Monkey	TBPL1-749C-B	Recombinant Cynomolgus Monkey TBPL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Cynomolgus Monkey	TBPL1-749C	Recombinant Cynomolgus Monkey TBPL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	TBPL1-11742Z	Recombinant Zebrafish TBPL1	Mammalian Cell	His		Inquiry
Chicken	TBPL1-6319C	Recombinant Chicken TBPL1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TBPL1 involved in several pathways and played different roles in them. We selected most pathways TBPL1 participated on our site, such as Basal transcription factors, Huntingtons disease, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Basal transcription factors	GTF2H2C_2;GTF2F2B;TAF12;TAF5;GTF2E2;GTF2A1L;GTF2IRD1;GTF2H5;TAF7
Huntingtons disease	BAX;NDUFA2;POLR2J3;GNAQ;UCP1;PLCB4;UQCRH;DNAI2;POLR2L
HTLV-I infection	HLA-DOB;XBP1;TCF3;H2-AB1;MAP3K3;SFPI1;FZD6;HLA-DQB1;WNT7B
Herpes simplex infection	PER3;HLA-DPB1;TAF3;PVRL1B;HLA-F;CDC34;BLA;HLA-E;TNFB
Epstein-Barr virus infection	CCNA2;FGR;HLA-DPA1;POLR2H;H2-Q10;HLA-DQA2;HDAC1;CD40;PSMD1
Viral carcinogenesis	HIST1H2BH;GTF2A2;PIK3CD;TRADD;HIST1H2BB;EIF2AK2;HDAC9;HIST1H4B;HIST1H4A

TBPL1 has several biochemical functions, for example, DNA binding, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBPL1 itself. We selected most functions TBPL1 had, and list some proteins which have the same functions with TBPL1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HLX1;ENO1;ZFP787;HOXB1;RXRGB;GIN1;ZNF606;FOXP3A;PAX8
protein binding	CACYBP;AHNAK2;THRA;TMEM106B;IL1RAPL1;PIM1;OLFM3;ZNF155;DTX2
transcription coactivator activity	NEUROG3;MED20;RNF20;CCAR1;UBE2L3;SMARCD1;UTF1;CARM1;NEUROD1

TBPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBPL1.

GTF2A1; TNNT1; PRNP; GTF2A2; PMVK; PLIN3; RPL10; NDUFA6; RAB35; SLC35F6; PTCD3; ABCF3; IRAK4