tcf7
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  • Official Full Name
  • transcription factor 7 (T-cell specific, HMG-box)
  • Background
  • The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • TCF7; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7; TCF 1; T-cell-specific transcription factor 1; TCF-1; FLJ36364; MGC47735
Cat.#:TCF7-15HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinent Human TCF7 Protein, GST-tagged
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Cat.#:TCF7-3159HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TCF7, His-tagged
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Cat.#:TCF7-16564MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TCF7 Protein
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Cat.#:TCF7-6116CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TCF7
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Cat.#:TCF7-2043ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TCF7
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Cat.#:TCF7-1753HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TCF7 cell lysate
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Involved Pathway

TCF7 involved in several pathways and played different roles in them. We selected most pathways TCF7 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
PORCNL; BAMBIB; TBL1X; WIF1; SKP1; DKK1B; BTRC; DKK1; LRP5; AXIN1
Hippo signaling pathway
PARD6A; ACTB; BMP4; PRKCI; WNT7A; PPP2R2B; SMAD1; BMP8A; TEAD1; WTIP
Adherens junction
RAC1; INSRB; RHOAC; ACTG1; ERBB2; FGFR1; CTNND1; FYNB; Fert2; WAS
Melanogenesis
HRASB; WNT3; RAF1; PRKCG; FZD3A; WNT4A; MAP2K2B; FZD7B; WNT1; WNT5A
Pathways in cancer
FGF21; DAPK3; CTNNA3; FGF20; MMP9; PTEN; SFPI1; CXCR4; PRKCA; WNT5B
Colorectal cancer
PIK3CA; PIK3CD; PIK3R1; SMAD2; PIK3R5; BAX; TGFBR2; BRAF; CCND1; RAC3
Endometrial cancer
LEF1; PDPK1; GRB2; MAPK3; ILK; CDH1; PIK3R5; BAD; PIK3CD; PTEN
Prostate cancer
IGF1R; INSRR; BAD; IKBKG; INS2; PIK3R1; MDM2; ERBB2; PDGFC; INS
Thyroid cancer
PPARG; RXRB; TFG; MAPK3; BRAF; TRP53; NTRK1; NCOA4; CDH1; CCDC6
Basal cell carcinoma
TRP53; STK36; PTCH1; SMO; AXIN1; WNT3A; WNT10B; SETD6; FZD5; APC
Acute myeloid leukemia
RARA; ZBTB16; EIF4EBP1; PIK3CG; STAT5B; KRAS; CEBPA; SPI1; SFPI1; PIK3R3
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGB4; TCF7; ITGA8; DSC2; ITGA1; SGCB; EMD; TCF7L2; SGCA; CTNNA3

Protein Function

TCF7 has several biochemical functions, for example, beta-catenin binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7 itself. We selected most functions TCF7 had, and list some proteins which have the same functions with TCF7. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein NF2; CDH24; DACT1; BTRC; KLF4; PROP1; CTNNA1; CTNNA3; APC; CARM1
Function chromatin binding
Related Protein NEUROD1; HDAC7; LEF1; L3MBTL1; PLAC8; BEND6; HMGB3B; SNAI2; ORC1L; GATA1A
Function protein binding
Related Protein MTMR9; HMGB4; PTPRM; IFIH1; CORO1C; SETD6; SLC11A2; RPN1; TFB1M; NSMCE1
Function sequence-specific DNA binding
Related Protein FOXG1C; PKNOX1; MEOX2; MNX2A; NKX3; FOXL2; HES1; NR2E3; FOXP2; RAB11FIP4A
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZFP518A; SOX11; CEBPA; ZFP628; CREB3L3A; TSC22D3; HSF2; ZNF92; KAT7; TBX2B
Function transcription regulatory region DNA binding
Related Protein MEN1; HNF4A; ETV5; TRP63; NKX3; MESP1; EGR2; ZFP746; CARM1; CEBPA

Interacting Protein

TCF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7.
CTNNB1; BCR; RUNX3