tcf7
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  • Official Full Name
  • transcription factor 7 (T-cell specific, HMG-box)
  • Background
  • The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • TCF7; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7; TCF 1; T-cell-specific transcription factor 1; TCF-1; FLJ36364; MGC47735
Cat.#:TCF7-3159HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TCF7, His-tagged
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Cat.#:TCF7-16564MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TCF7 Protein
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Cat.#:TCF7-6116CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TCF7
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Cat.#:TCF7-2043ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TCF7
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Cat.#:TCF7-1753HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TCF7 cell lysate
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Involved Pathway

TCF7 involved in several pathways and played different roles in them. We selected most pathways TCF7 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
PORCN; CCND3; NFATC1; PPP3R1B; SFRP2; AXIN1; WNT7B; FZD3B; PRKCB; FBXW11
Hippo signaling pathway
WTIP; PPP2R1A; WNT5A; FZD9; LATS2; LLGL2; INADL; GDF7; NF2; FZD7
Adherens junction
RHOAC; WASF3; WASF3B; TGFBR1; PTPRFB; LMO7A; CDC42; ACTN3A; ACTN3B; CTNNA1
Melanogenesis
FZD8A; MITFB; FZD7; CAMK2D2; WNT2BA; GSK3B; GNAI2B; TCF7L1A; CREB3L3; FZD3A
Pathways in cancer
PML; BIRC2; BMP2; APC2; SKP2; RUNX1; MET; STAT1; ITGB1; MTOR
Colorectal cancer
CCND1; PIK3R5; BAX; TGFBR2; AXIN2; MSH2; BRAF; SMAD4; TGFB1; PIK3CA
Endometrial cancer
MLH1; PTEN; PIK3CB; TRP53; AXIN1; ILK; GSK3B; CTNNA3; TCF7; FOXO3
Prostate cancer
SOS1; ARAF; INS2; MDM2; MAPK1; PIK3CB; TCF7; NFKB1; SMARCC2; ARID1A
Thyroid cancer
MAPK1; PPARG; TPR; KRAS; TCF7; CCDC6; TFG; NCOA4; LEF1; MAPK3
Basal cell carcinoma
AXIN2; APC2; GLI1; FZD2; FZD9; WNT2; WNT7B; FZD7; PTCH1; TCF7L2
Acute myeloid leukemia
NRAS; PIK3CD; PIK3R1; PIK3CG; CHUK; STAT5B; CCNA1; MTOR; CEBPA; RARA
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
CACNA2D4; DAG1; ITGA7; DSP; CDH2; ITGA9; ITGAV; ACTN1; JUP; LEF1

Protein Function

TCF7 has several biochemical functions, for example, beta-catenin binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7 itself. We selected most functions TCF7 had, and list some proteins which have the same functions with TCF7. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein DACT1; CDH5; CTNNA1; PTPRJ; TAX1BP3; PTPRU; CARM1; TCF7; TCF7L1B; SOX9
Function chromatin binding
Related Protein KAT2A; TOP2B; TSHZ3; MED12; GATA4; URI1; JARID2B; CREBBP; SETD7; TWIST2
Function protein binding
Related Protein KCNMA1; CIB1; MPG; PRICKLE1; COG3; PREP; CASP9; LDB3; TRIM16; AXIN2
Function sequence-specific DNA binding
Related Protein NKX2.2A; POU3F2B; IRX3A; MAFBB; IRX6; CSRNP2; SIX1B; NKX2.5; BSX; MSXB
Function transcription factor activity, sequence-specific DNA binding
Related Protein GAS7; TLX2; SCML2; BATF3; SCAND2P; MEF2D; NKX2-5; ARNTL1B; TRIM29; CITED2
Function transcription regulatory region DNA binding
Related Protein NCOR1; CREB3L2; ZNF567; ZNF831; LEF1; HHEX; HIVEP2A; CREB3L1; CARM1; WNT11

Interacting Protein

TCF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7.
CTNNB1; BCR; RUNX3