TCF7 Protein, transcription factor 7 (T-cell specific, HMG-box)

TCF7

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TCF7

Official Full Name transcription factor 7 (T-cell specific, HMG-box)
Background The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms TCF7; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7; TCF 1; T-cell-specific transcription factor 1; TCF-1; FLJ36364; MGC47735
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TCF7-15H Recombinant Human TCF7 Protein, GST-tagged Wheat Germ GST
    Human TCF7-1753HCL Recombinant Human TCF7 cell lysate N/A
    Human TCF7-3159H Recombinant Human TCF7, His-tagged E.coli His
    Mouse TCF7-16564M Recombinant Mouse TCF7 Protein Mammalian Cell His
    Chicken TCF7-6116C Recombinant Chicken TCF7 Mammalian Cell His
    Zebrafish TCF7-2043Z Recombinant Zebrafish TCF7 Mammalian Cell His

    TCF7 involved in several pathways and played different roles in them. We selected most pathways TCF7 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway DKK1B; WNT8B; EP300; TCF7L1A; PRKACB; RAC1B; NFATC2; FZD6; DAAM2; FRAT2
    Hippo signaling pathway PPP2R2B; STK3; LIMD1; DLG3; FBXW11; YAP1; WNT8A; WNT7B; ID1; RASSF1
    Adherens junction RHOAB; RAC1; PVRL1; Fert2; WASF2; TCF7; ACTN3; ERBB2; YES1; FYNB
    Melanogenesis GNAS; KITLG; GNAI1; PRKACG; CALM1A; LEF1; PRKCG; PLCB3; PRKACBB; EDNRBA
    Pathways in cancer BIRC3; GNG8; WNT9B; ETS1; PDGFA; MAPK9; TRAF3; PLCG2; BAD; FOXO1
    Colorectal cancer RHOA; TGFB1; AXIN2; TP53; MAPK3; TGFBR1; PIK3R2; GSK3B; APC2; MLH1
    Endometrial cancer TRP53; MAPK3; GSK3B; TCF7; PIK3CA; CTNNA2; PIK3R1; PIK3CB; MAP2K2; CASP9
    Prostate cancer MAPK1; TCF7L2; KRAS; Pdgfa&Pdgfb; PIK3R3; AKT1; SPRY1; IKBKG; GSTP1; NFKBIA
    Thyroid cancer MAP2K2; CCND1; TCF7; PAX8; TCF7L2; TRP53; NCOA4; KRAS; NTRK1; MAPK3
    Basal cell carcinoma WNT7A; WNT9B; APC; DVL1; WNT7B; WNT2B; FZD1; WNT2; TP53; WNT16
    Acute myeloid leukemia RAF1; KRAS; AKT2; PML; EIF4EBP1; PIK3CA; MAP2K2; PIM2; RELA; PIK3R2
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA2B; ITGA3; CACNG8; ITGA9; CACNA2D1; CACNB4; ACTB; ITGA7; ITGB6; RYR2

    TCF7 has several biochemical functions, for example, beta-catenin binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7 itself. We selected most functions TCF7 had, and list some proteins which have the same functions with TCF7. You can find most of the proteins on our site.

    Function Related Protein
    beta-catenin binding RORA; CHD8; CDH5; DACT3; PTPRJ; CBY1; PTPRK; MED12; CARM1; CTNNA1
    chromatin binding ANKRD2; HMGB4; MEF2C; MBD5; REST; UBTF; PHF21B; CITED1; NKX6-1; ZEB1
    protein binding STXBP4; GAPDH; TEX264; TMEM93; NR2F1; TATDN1; TMEM132D; PAIP2; C14orf159; MAP1LC3B
    sequence-specific DNA binding IRX5A; HSFX1; ZKSCAN3; WHSC1; PRDM16; GSX1; DBX1B; NR2E1; ZSCAN23; IRX2A
    transcription factor activity, sequence-specific DNA binding KLF9; ZNF35; HSF5; PPARD; GPBP1L1; POU3F3B; TAF5L; TSC22D1; PLAGX; ZNF812
    transcription regulatory region DNA binding CDK9; ATF3; NR1D1; MZF1; KLF15; RFX3; XRCC5; WNT1; TNF; TRP63

    TCF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7.

    CTNNB1; BCR; RUNX3

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