Recombinant Human TCF7 Protein, His-tagged

• Cat.No.: TCF7-119H
• Product Overview: Recombinant Human TCF7 Protein, fused to His-tag, was expressed in E.coli.

Specification

• Description: This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Supplied as a 0.2 μm filtered solution in 25mM Tris, 0.3M NaCl, 0.1 mM EDTA, 50% glycerol, pH 7.4.
• Molecular Mass: ~45.2 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMASMT GGQQMGRGSMPQLDSGGGGAGGGDD LGAPDELLAFQDEGEEQDDKSRDSA AGPERDLAELKSSLVNESEGAAGGA GIPGVPGAGAGARGEAEALGREHAA QRLFPDKLPEPLEDGLKAPECTSGM YKETVYSAFNLLMHYPPPSGAGQHP QPQPPLHKANQPPHGVPQLSLYEHF NSPHPTPAPADISQKQVHRPLQTPD LSGFYSLTSGSMGQLPHTVSWFTHP SLMLGSGVPGHPAAIPHPAIVPPSG KQELQPFDRNLKTQAESKAEKEAKK PTIKKPLNAFMLYMKEMRAKVIAEC TLKESAAINQILGRRWHALSREEQA KYYELARKERQLHMQLYPGWSARDN YGKKKRRSREKHQESTTETNWPREL KDGNGQESLSMSSSSSPA
• Endotoxin: <1EU/ug
• Purity: >90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: TCF7 transcription factor 7 [ Homo sapiens (human) ]
• Official Symbol: TCF7
• Synonyms: TCF-1
• Gene ID: 6932
• mRNA Refseq: NM_001134851
• Protein Refseq: NP_001128323
• MIM: 189908
• UniProt ID: P36402