TDP2
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Official Full Name
tyrosyl-DNA phosphodiesterase 2
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Overview
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. -
Synonyms
EAP2; AD022; TTRAP; MGC9099; dJ30M3.3; MGC111021; RP1-30M3.3; tyrosyl-DNA phosphodiesterase 2; EAPII; OTTHUMP00000016091; OTTHUMP00000016092; ETS1-associated protein 2; ETS1-associated protein II; tyr-DNA phosphodiesterase 2; 5"-Tyr-DNA phosphodiesterase; 5"-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associated protein; TRAF and TNF receptor-associated protein; TDP2; tyrosyl-DNA phosphodiesterase 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | TDP2-7580H | Recombinant Human TDP2, His-tagged | E.coli | His | 1-362aa |
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| Human | TDP2-664HCL | Recombinant Human TTRAP 293 Cell Lysate | HEK293 | N/A |
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| Human | TDP2-6706H | Recombinant Human TDP2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | TDP2-16603M | Recombinant Mouse TDP2 Protein | Mammalian Cell | His |
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| Mouse | TDP2-9104M | Recombinant Mouse TDP2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Tdp2-6348M | Recombinant Mouse Tdp2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | TDP2-9104M-B | Recombinant Mouse TDP2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | TDP2-5999R | Recombinant Rat TDP2 Protein | Mammalian Cell | His |
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| Rat | TDP2-5658R | Recombinant Rat TDP2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | TDP2-5658R-B | Recombinant Rat TDP2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | TDP2-4713C | Recombinant Chicken TDP2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
TDP2 involved in several pathways and played different roles in them. We selected most pathways TDP2 participated on our site, such as CD40/CD40L signaling, DNA Double-Strand Break Repair, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CD40/CD40L signaling | JAK3;MYC;TDP2 |
| DNA Double-Strand Break Repair | PPP4CA;RHNO1;GEN1;CLSPN;WRN;HUS1;EYA3;CHEK1;RNF168 |
| DNA Repair | ACTR5;USP10;POLD3;TDP2;THRSP;COPS6;PPIE;CETN2;RAD18 |
| Nonhomologous End-Joining (NHEJ) | TDP1;TDP2;RIF1;PAXIP1;TDP2B |
TDP2 has several biochemical functions, for example, 5-tyrosyl-DNA phosphodiesterase activity, magnesium ion binding, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDP2 itself. We selected most functions TDP2 had, and list some proteins which have the same functions with TDP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 5-tyrosyl-DNA phosphodiesterase activity | TDP2;TDP2B |
| magnesium ion binding | GLUL;FEN1;ALPI;MAST4;IDH2;PPM1BA;ATP8B3;GCLC;ADPRHL1 |
| manganese ion binding | WRN;PPM1AB;PIM1;GLUL;ARG1;PPM1NB;TDP2B;XPNPEP3;ABL1 |
| nuclease activity | EAR2;GDPD4;TMPPE;CNOT6L;RNASEKA;REXO4;MRE11A;SMG6;DNA2 |
| protein binding | MIF;TEK;SNX9;STK40;ZNF256;RG9MTD1;LRGUK;HDGF2;CSPG5 |
| single-stranded DNA binding | HSPD1;SSBP2;PCBP1;BLM;NABP2;HMGB2;POLR2G;HNRNPA1;RAD51D |
| transcription corepressor activity | C1QBP;PBXIP1;BRD7;JUNB;MECP2;TRIM28;SSX3;ATF5;HSBP1 |
| tyrosyl-RNA phosphodiesterase activity |
TDP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDP2.
SRPK2; DLX3; SKIL; ETS1; PSEN1; ATXN1; JAM2; RAB11A; SMAD3; TAP1; ATP5G2; EPS8; MAPK6; q81xc2_bacan; AKAP9; C2orf88; SNX13
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