tdp2
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  • Official Full Name
  • tyrosyl-DNA phosphodiesterase 2
  • Background
  • This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
  • Synonyms
  • EAP2; AD022; TTRAP; MGC9099; dJ30M3.3; MGC111021; RP1-30M3.3; tyrosyl-DNA phosphodiesterase 2; EAPII; OTTHUMP00000016091; OTTHUMP00000016092; ETS1-associated protein 2; ETS1-associated protein II; tyr-DNA phosphodiesterase 2; 5"-Tyr-DNA phosphodiesterase; 5"-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associated protein; TRAF and TNF receptor-associated protein; TDP2; tyrosyl-DNA phosphodiesterase 2
Cat.#:TDP2-7580HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TDP2, His-tagged
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Cat.#:TDP2-16603MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TDP2 Protein
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Cat.#:TDP2-5999RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TDP2 Protein
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Cat.#:TDP2-4713CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TDP2
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Cat.#:TDP2-664HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TTRAP 293 Cell Lysate
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Involved Pathway

TDP2 involved in several pathways and played different roles in them. We selected most pathways TDP2 participated on our site, such as CD40/CD40L signaling, DNA Double-Strand Break Repair, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDP2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
CD40/CD40L signaling
JAK3; MYC; TDP2
DNA Double-Strand Break Repair
TIPIN; BAZ1B; RIF1; RAD9; PARP2; EYA3; RAD9B; PPP4R2B; TIMELESS; HTATIP
DNA Repair
KDM4A; RAD51AP1; ZFP830; CETN2; TOPBP1; TDP2; EYA4; PIAS3; ACTL6A; ACTR5
Nonhomologous End-Joining (NHEJ)
RIF1; TDP2; PAXIP1; TDP1; TDP2B

Protein Function

TDP2 has several biochemical functions, for example, 5-tyrosyl-DNA phosphodiesterase activity, magnesium ion binding, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDP2 itself. We selected most functions TDP2 had, and list some proteins which have the same functions with TDP2. You can find most of the proteins on our site.
Function
Related Protein
Function 5-tyrosyl-DNA phosphodiesterase activity
Related Protein TDP2B; TDP2
Function magnesium ion binding
Related Protein STK11; STK38; PAPOLA; TREX2; NLRC4; SIK2; ATP8B5; FARS2; MAP3K6; FAN1
Function manganese ion binding
Related Protein ATP2C1; DYRK2; GYLTL1B; PCK1; PPM1N; PPEF2; XPNPEP1; NPEPL1; PPM1NB; HMGCL
Function nuclease activity
Related Protein EXO5; EAR3; SMG6; RNASEKB; MRE11A; EXOSC9; ANG3; CNOT6; MEIOB; FANCM
Function protein binding
Related Protein DYNC1H1; HSP90B1; FZD5; TGM1; CCDC85B; LINC01588; PEX10; XCL2; FBXL14; FHOD1
Function single-stranded DNA binding
Related Protein TDP2; DDX11; WBP11; RAD51C; HNRNPA1; PURA; NEIL3; TDP2B; XPC; POLR2G
Function transcription corepressor activity
Related Protein ATF3; HDAC4; NFIL3; PAWR; MNT; HOMEZA; ERF; ID4; CSDA; SIAH2
Function tyrosyl-RNA phosphodiesterase activity
Related Protein TDP2

Interacting Protein

TDP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDP2.
SRPK2; DLX3; SKIL; ETS1; PSEN1; ATXN1; JAM2; RAB11A; SMAD3; TAP1; ATP5G2; EPS8; MAPK6; q81xc2_bacan; AKAP9; C2orf88; SNX13