tdp2
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  • Official Full Name
  • tyrosyl-DNA phosphodiesterase 2
  • Background
  • This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
  • Synonyms
  • EAP2; AD022; TTRAP; MGC9099; dJ30M3.3; MGC111021; RP1-30M3.3; tyrosyl-DNA phosphodiesterase 2; EAPII; OTTHUMP00000016091; OTTHUMP00000016092; ETS1-associated protein 2; ETS1-associated protein II; tyr-DNA phosphodiesterase 2; 5"-Tyr-DNA phosphodiesterase; 5"-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associated protein; TRAF and TNF receptor-associated protein; TDP2; tyrosyl-DNA phosphodiesterase 2
Cat.#:TDP2-7580HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TDP2, His-tagged
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Cat.#:TDP2-16603MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TDP2 Protein
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Cat.#:TDP2-5999RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TDP2 Protein
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Cat.#:TDP2-4713CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TDP2
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Cat.#:TDP2-664HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TTRAP 293 Cell Lysate
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Involved Pathway

TDP2 involved in several pathways and played different roles in them. We selected most pathways TDP2 participated on our site, such as CD40/CD40L signaling, DNA Double-Strand Break Repair, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
CD40/CD40L signaling
MYC; JAK3; TDP2
DNA Double-Strand Break Repair
EYA4; RAD9B; CHEK2; TIMELESS; FAM175A; TP53BP1; PPP4R2B; RBBP8; TOPBP1; EYA3
DNA Repair
MAD2L2; PPP4CB; APITD1; TIMELESS; TDP2B; RAD9A; TOPBP1; ACTR5; ASCC3; USP45
Nonhomologous End-Joining (NHEJ)
TDP2; RIF1; TDP2B; TDP1; PAXIP1

Protein Function

TDP2 has several biochemical functions, for example, 5-tyrosyl-DNA phosphodiesterase activity, magnesium ion binding, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDP2 itself. We selected most functions TDP2 had, and list some proteins which have the same functions with TDP2. You can find most of the proteins on our site.
Function
Related Protein
Function 5-tyrosyl-DNA phosphodiesterase activity
Related Protein TDP2; TDP2B
Function magnesium ion binding
Related Protein PPM1BB; NT5C1AA; PIF1; ATP9A; PRTFDC1; STK4; PDXP; MAST4; CIB4; THTPA
Function manganese ion binding
Related Protein PEPD; PPM1M; PPM1NB; LAP3; LARGE; NUDT16; PPM1AA; PCK1; PPEF1; NUDT7
Function nuclease activity
Related Protein DOM3Z; MEIOB; PARN; TDP2B; ZRANB3; RAD9; CNOT6; DNASE1L3L; GDPD4; DNASE2A
Function protein binding
Related Protein PRLR; MAP2K5; TIMM44; JUB; C1QBP; FAT4; BTN2A2; IL11; CCDC148; CREM
Function single-stranded DNA binding
Related Protein NCL; RAD51D; PURB; OBFC1; SSBP3B; SUB1; HNRNPDL; HNRNPK; NABP1A; MCM7
Function transcription corepressor activity
Related Protein CSDA; SKOR1A; YAF2; DNMT3B; TAF9B; ZHX1; IRF2BP2; TBL1XR1B; PRMT5; SAP30
Function tyrosyl-RNA phosphodiesterase activity
Related Protein TDP2

Interacting Protein

TDP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDP2.
SRPK2; DLX3; SKIL; ETS1; PSEN1; ATXN1; JAM2; RAB11A; SMAD3; TAP1; ATP5G2; EPS8; MAPK6; q81xc2_bacan; AKAP9; C2orf88; SNX13