TFEB
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Official Full Name
transcription factor EB
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Overview
Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3-CANNTG-5). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the -
Synonyms
TFEB; transcription factor EB; bHLHe35; TCFEB; T-cell transcription factor EB; class E basic helix-loop-helix protein 35; ALPHATFEB;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- T7|His
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | TFEB-212H | Recombinant Human TFEB protein, T7/His-tagged | E.coli | T7/His |
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| Human | TFEB-3202H | Recombinant Human TFEB, GST-tagged | E.coli | GST | 1-476aa | |
| Human | TFEB-635H | Recombinant Human TFEB Protein, His-tagged | E.coli | His |
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| Human | TFEB-1128HCL | Recombinant Human TFEB 293 Cell Lysate | HEK293 | N/A |
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| Human | TFEB-6592H | Recombinant Human TFEB Protein (Full Length), N-His tagged | E.coli | N-His | Full Length |
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| Human | TFEB-6591H | Recombinant Human TFEB Protein (Met1-Leu476), N-His tagged | E.coli | N-His | Met1-Leu476 |
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| Rhesus Macaque | TFEB-4680R | Recombinant Rhesus monkey TFEB Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | TFEB-4496R | Recombinant Rhesus Macaque TFEB Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | TFEB-4496R-B | Recombinant Rhesus Macaque TFEB Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | TFEB-8212Z | Recombinant Zebrafish TFEB | Mammalian Cell | His |
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| Chicken | TFEB-2611C | Recombinant Chicken TFEB | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- TFEB Related Articles
- TFEB Related Research Area
TFEB involved in several pathways and played different roles in them. We selected most pathways TFEB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TFEB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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TFEB has several biochemical functions, for example, protein dimerization activity, transcription factor activity, sequence-specific DNA binding, transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFEB itself. We selected most functions TFEB had, and list some proteins which have the same functions with TFEB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | NCOA1;ASCL3;MESPAA;PTF1A;STAT5B;ID2;SCXA;PEX3;FBXW11A |
| transcription factor activity, sequence-specific DNA binding | SUPT6H;MESP1;EOMESB;GATA2B;NEUROD2;ARNT;NR1D2A;RXRA;ZNF396 |
| transcription regulatory region DNA binding | HIVEP2A;SMAD4;TAF2;PPARG;SOX2;POU5F1;NKX2-5;RFX6;SALL3 |
TFEB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFEB here. Most of them are supplied by our site. Hope this information will be useful for your research of TFEB.
SRPK1; q81ni5_bacan; PPM1G; MITF; BAG2; MT-CO2; IFIT1; MAPT; ATP5J; TFE3; STT3A; C10orf12; EML4; TBC1D14
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, TFEB activation can enhance the autophagic process by upregulating the expression of autophagy-related genes and promoting the formation of autophagosomes.
TFEB activation has been shown to enhance the clearance of protein aggregates commonly associated with neurodegenerative disorders, offering potential therapeutic benefits.
Several small molecule compounds have been identified as potential TFEB activators, and their therapeutic potential is being explored in preclinical studies.
TFEB regulates the expression of genes involved in lysosomal biogenesis, promoting the formation and function of lysosomes.
Yes, TFEB has been shown to regulate the expression of genes involved in inflammation, suggesting its potential role in modulating the immune response.
Customer Reviews (3)
Write a reviewOne notable advantage of the TFEB protein is the outstanding technical support provided by the manufacturer.
One aspect that sets the TFEB protein apart is the excellent technical support provided by the manufacturer.
The TFEB protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.
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